Results 151 to 160 of about 2,982,557 (298)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice. [PDF]

Redox Biol, 2023
Song LL, Qu YQ, Tang YP, Chen X, Lo HH, Qu LQ, Yun YX, Wong VKW, Zhang RL, Wang HM, Liu MH, Zhang W, Zhang HX, Chan JTW, Wang CR, Wu JH, Law BYK.   +16 more
europepmc   +1 more source

Editorial: The circadian circus – how our clocks keep us ticking

Frontiers in Neuroscience, 2022
Alun Thomas Lloyd Hughes, Hrayr P. Attarian, Jun Hirayama, Jun Hirayama   +3 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons. [PDF]

J Cell Physiol, 2021
Kamynina A, Esteras N, Koroev DO, Angelova PR, Volpina OM, Abramov AY.   +5 more
europepmc   +1 more source

MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap

Nature Communications
The tactile sense is essential for living organisms. However, the molecular mechanisms of mechanosensing in plants remain unclear. The Venus flytrap (Dionaea muscipula), a carnivorous plant, possesses mechanosensitive organs called sensory hairs.
Hiraku Suda, Hiroki Asakawa, Takuma Hagihara, Shoko Ohi, Shoji Segami, Mitsuyasu Hasebe, Masatsugu Toyota   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation. [PDF]

Cell Rep, 2021
Baraniak JH, Zhou Y, Nwokonko RM, Jennette MR, Kazzaz SA, Stenson JM, Whitsell AL, Wang Y, Trebak M, Gill DL.   +9 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Molecular dynamics provides new insights into the mechanism of calcium signal transduction and interdomain interactions in cardiac troponin. [PDF]

FEBS Open Bio, 2021
Genchev GZ, Kobayashi M, Kobayashi T, Lu H.   +3 more
europepmc   +1 more source