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Induction of Epithelial–Mesenchymal Transition (EMT) in Breast Cancer Cells Is Calcium Signal Dependent [PDF]
Oncogene, 2014 Signals from the tumor microenvironment trigger cancer cells to adopt an invasive phenotype through epithelial-mesenchymal transition (EMT). Relatively little is known regarding key signal transduction pathways that serve as cytosolic bridges between ...
Sarah J Roberts-Thomson +2 more
exaly +2 more sources
Cytosolic Calcium Oscillations in Signal Transduction Pathways
Mini-Reviews in Medicinal Chemistry, 2002 The oscillatory nature of the intracellular calcium signal has been recognized as soon as the methodological developments allowed us to record calcium fluctuations at the single cell level. While the principal mechanisms responsible for the generation of
Michel Florian Rossier
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Calcium signalling in astroglia
Molecular and Cellular Endocrinology, 2012Astroglia possess excitability based on movements of Ca(2+) ions between intracellular compartments and plasmalemmal Ca(2+) fluxes. This "Ca(2+) excitability" is controlled by several families of proteins located in the plasma membrane, within the cytosol and in the intracellular organelles, most notably in the endoplasmic reticulum (ER) and ...
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898 +2 more
openaire +3 more sources
Cellular and Molecular Life Sciences, 2000
The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic gradients. The reasons why some labs have recorded such gradients, whilst other workers see equilibration of Ca2+(cyt) and Ca2+(nuc) using the same cells and techniques, is unexplained.
M D, Bootman +4 more
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The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic gradients. The reasons why some labs have recorded such gradients, whilst other workers see equilibration of Ca2+(cyt) and Ca2+(nuc) using the same cells and techniques, is unexplained.
M D, Bootman +4 more
openaire +2 more sources
Calcium signaling in platelets
Journal of Thrombosis and Haemostasis, 2009Agonist-induced elevation in cytosolic Ca2+ concentrations is essential for platelet activation in hemostasis and thrombosis. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane (PM). Ca2+ store release is a well-established process involving phospholipase (PL)C-mediated production of inositol-1,4,5 ...
D, Varga-Szabo, A, Braun, B, Nieswandt
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Calcium signalling in lymphocytes
Current Opinion in Immunology, 2003The modulation of intracellular calcium ion concentration, [Ca(2+)](i), is a common signalling mechanism used in many biological systems. B and T lymphocytes rely on Ca(2+) signalling to initiate both developmental and activation programs. Recent data has shed new light on the initiation of this signalling pathway, the connection between the release of
Monte M, Winslow +2 more
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Cell Calcium, 2005
In hepatocytes, hormones linked to the formation of the second messenger inositol 1,4,5-trisphosphate (InsP3) evoke transient increases or spikes in cytosolic free calcium ([Ca2+]i), that increase in frequency with the agonist concentration. These oscillatory Ca2+ signals are thought to transmit the information encoded in the extracellular stimulus to ...
Lawrence D, Gaspers, Andrew P, Thomas
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In hepatocytes, hormones linked to the formation of the second messenger inositol 1,4,5-trisphosphate (InsP3) evoke transient increases or spikes in cytosolic free calcium ([Ca2+]i), that increase in frequency with the agonist concentration. These oscillatory Ca2+ signals are thought to transmit the information encoded in the extracellular stimulus to ...
Lawrence D, Gaspers, Andrew P, Thomas
openaire +2 more sources
Calcium Signaling and Annexins
Cell Biochemistry and Biophysics, 2000The annexins, are a family of calcium ion (Ca2+)-binding proteins whose physiological functions are poorly understood. Although many diverse functions have been proposed for these proteins, such as in vesicle trafficking, this review focuses on their proposed roles as Ca2+ or other ion channels, or as intracellular ion channel regulators.
T E, Hawkins, C J, Merrifield, S E, Moss
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Calcium signaling at fertilization
Current Biology, 1992Calcium is well established as a second messenger in a diverse array of cell activities. Changes in intracellular Ca2+ activities range from localized releases to complex oscillations, which may encode specific cellular signals. The full variety of calcium responses is observed during the fertilization of different animal oocytes and eggs.
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Cell Calcium, 2011
The placenta sustains the developing fetus throughout gestation and its major functions include nutrition, gas and waste exchange via a variety of passive or active mechanisms. Up to 30 g of calcium (Ca(2+)) actively crosses the trophoblast layer during human pregnancy.
Dora, Baczyk +2 more
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The placenta sustains the developing fetus throughout gestation and its major functions include nutrition, gas and waste exchange via a variety of passive or active mechanisms. Up to 30 g of calcium (Ca(2+)) actively crosses the trophoblast layer during human pregnancy.
Dora, Baczyk +2 more
openaire +2 more sources