Results 71 to 80 of about 2,982,557 (298)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Pharmacological Intervention of PIEZO1 for Butterfly Eyespot Color Patterns in Junonia orithya

Receptors
Background: PIEZO channels are mechanoreceptors expressed in various cells. Their contributions to animal development are not entirely clear. According to the physical distortion hypothesis, developmental organizers for butterfly wing eyespots receive ...
Momo Ozaki, Joji M. Otaki
doaj   +1 more source

Synapse Calcium Image Analysis (SCIA): A Groundbreaking Toolkit for Real-Time Analysis of synaptic Calcium Signals [PDF]

BIO Web of Conferences
With the continuous advancement of fluorescence microscopy technology and improved fluorescent indicators, we can now record neuronal calcium activity with unprecedented resolution and signal- to-noise ratio. By using calcium sensors to monitor and track
Li Ting, Wei Hengqi, Zhao Congjian
doaj   +1 more source

CCN3 and calcium signaling [PDF]

Cell Communication and Signaling, 2003
The CCN family of genes consists presently of six members in human (CCN1-6) also known as Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), NOV (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). Results obtained over the past decade have indicated that CCN proteins are matricellular proteins, which ...
Li Chang Long, Bleau Anne-Marie, Planque Nathalie, Lombet Alain, Perbal Bernard   +4 more
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Piezo2 inhibition enhances the survival and axonal regeneration of spinal motoneurons after brachial plexus avulsion

Neural Regeneration Research
Piezo-type mechanosensitive ion channel component 2 (Piezo2) is a mechanosensitive ion channel that plays essential roles in various biological processes, such as the maintenance of sensory neuron functionality.
Yunsong Zhang, Fengwei Sun, Jin Wo, Lingtai Yu, Huandi Weng, Zhonghai Huang, Wen Li, Bin Jia, Meiting He, Ang Li, Libing Zhou   +10 more
doaj   +1 more source

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

Cell Reports, 2017
Mitochondrial Ca2+ uptake through the Ca2+ uniporter supports cell functions, including oxidative metabolism, while meeting tissue-specific calcium signaling patterns and energy needs.
Melanie Paillard, György Csordás, Gergö Szanda, Tünde Golenár, Valentina Debattisti, Adam Bartok, Nadan Wang, Cynthia Moffat, Erin L. Seifert, András Spät, György Hajnóczky   +10 more
doaj   +1 more source

Calcium signalling—an overview

Seminars in Cell & Developmental Biology, 2001
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability of a simple ion such as Ca2+ to play a pivotal role in cell biology results from the facility that cells have to shape Ca2+ signals in the dimensions of ...
M D, Bootman, T J, Collins, C M, Peppiatt, L S, Prothero, L, MacKenzie, P, De Smet, M, Travers, S C, Tovey, J T, Seo, M J, Berridge, F, Ciccolini, P, Lipp   +11 more
openaire   +3 more sources

Cellular and nuclear morphology…and calcium signaling: revealing the interplay between structure and function [PDF]

, 2012
Poster presentation: Calcium plays a pivotal role in relaying electrical signals of the cell to subcellular compartments, such as the nucleus. Since this one ion type is used by the cell for many processes a neuron needs to establish finely tuned calcium
Queisser, Sean Gillian, Hagenston, Anna, Breit, Markus, Bengtson, Peter von der, Bading, Hilmar, Markus Breit, Anna Hagenston, Hagenston Anna, Queisser Gillian, Hilmar Bading, Peter Bengtson, Bengtson Peter, Bading Hilmar, Gillian Queisser, Breit Markus   +14 more
core   +1 more source