Results 51 to 60 of about 2,982,557 (298)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]

, 2008
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Kummer, U. (Ursula), Green, Anne K., Green, A. K., Kummer, U., Pahle, J., Pahle, Jürgen, Dixon, C. Jane, Dixon, C. J., Dixon C Jane, Kummer Ursula, Green Anne K, Pahle Jürgen   +11 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Targeting the calcium ATPase to the endoplasmic reticulum

, 2009
The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from thecytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removingexcess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located inboth
Watson, Helen Rachel
core   +1 more source

Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages

Cell Death and Disease, 2022
The danger signal extracellular calcium is pathophysiologically increased in the synovial fluid of patients with rheumatoid arthritis (RA). Calcium activates the NLRP3-inflammasome via the calcium-sensing receptor in monocytes/macrophages primed by ...
Supriya Murthy, Isabel Karkossa, Caroline Schmidt, Anne Hoffmann, Tobias Hagemann, Kathrin Rothe, Olga Seifert, Ulf Anderegg, Martin von Bergen, Kristin Schubert, Manuela Rossol   +10 more
doaj   +1 more source

Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

mBio, 2021
The marine bacterium Vibrio fischeri colonizes its host, the Hawaiian bobtail squid, in a manner requiring both bacterial biofilm formation and motility. The decision to switch between sessile and motile states is often triggered by environmental signals
Alice H. Tischler, Michael E. Vanek, Natasha Peterson, Karen L. Visick   +3 more
doaj   +1 more source

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Najl V Valeyev, Nikolay V Kotov, Kotov, Nikolay, Bates D., Declan G. Heslop-Harrison (7606778), Heslop-Harrison, Pat, Postlethwaite, Ian, Declan G Bates, Najl V. Valeyev (7606775), Valeyev N., Ian Postlethwaite, Kotov N., Ian Postlethwaite (36312), Valeyev, Najil, Pat Heslop-Harrison, Nikolay V. Kotov (7606781), Bates, Declan, Heslop-Harrison P., Postlethwaite I., Declan G. Bates (2615086)   +19 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Characterization of PDGF-Induced Subcellular Calcium Regulation through Calcium Channels in Airway Smooth Muscle Cells by FRET Biosensors

Biosensors
The homeostasis of cellular calcium is fundamental for many physiological processes, while the calcium levels remain inhomogeneous within cells. During the onset of asthma, epithelial and inflammatory cells secrete platelet-derived growth factor (PDGF ...
Mingxing Ouyang, Binqian Zhou, Chunmei Li, Linhong Deng   +3 more
doaj   +1 more source

Signal-to-signal neural networks for improved spike estimation from calcium imaging data.

PLoS Computational Biology, 2021
Spiking information of individual neurons is essential for functional and behavioral analysis in neuroscience research. Calcium imaging techniques are generally employed to obtain activities of neuronal populations.
Jilt Sebastian, Mriganka Sur, Hema A Murthy, Mathew Magimai-Doss   +3 more
doaj   +1 more source