Results 51 to 60 of about 6,896 (176)
Movement Disorders, EarlyView.Abstract Background Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co‐occur. Their long‐term evolution remains incompletely characterized, particularly in biomarker‐positive cohorts.
Izabelle Schoen +10 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background The cerebellum is increasingly recognized as a key contributor to cognitive reserve and network organization in Parkinson's disease (PD). However, the relationship of cerebello‐cortical and cerebello‐basal ganglia connectivity with cognitive status and nigrostriatal integrity remains incompletely understood.
Chi‐Ying R. Lin +6 more
wiley +1 more source
Journal of Lipid ResearchBlood plasma is one of the most commonly analyzed and easily accessible biological samples. Here, we describe an automated liquid-liquid extraction platform that generates accurate, precise, and reproducible samples for metabolomic, lipidomic, and ...
Ngoc Vu +11 more
doaj +1 more source
Cross‐Cohort Evidence Links KCNJ6 rs702859 to Impulsive–Compulsive Phenotypes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Impulse control disorders (ICDs) and related compulsive behaviors (CBs) are frequent non‐motor complications of Parkinson's disease (PD) with a probable genetic contribution. Objective To investigate whether genetic variants involved in reward and punishment processing are associated with impulsive–compulsive phenotypes in PD ...
Sergio García‐Díaz +21 more
wiley +1 more source
, 2021 Green calico dress with white, yellow, and orange flowers. The top is a cross the chest wrap style with a bow tied at the waist on the side. The lapel turns into the sleeves as a continuous ruffle.
Day, Marla
core
eLife, 2019 For most adult mammals, the risk of death increases exponentially with age, an observation originally described for humans by Benjamin Gompertz. We recently performed a Kaplan–Meier survival analysis of naked mole-rats (Heterocephalus glaber) and ...
J Graham Ruby +2 more
doaj +1 more source
The landscape of alternative polyadenylation in single cells of the developing mouse embryo
Nature Communications, 2021 Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal +3 more
doaj +1 more source
Muscle &Nerve, EarlyView.This scoping review summarizes the spectrum of upper extremity assistive devices for adults with progressive neuromuscular diseases, ranging from low‐tech supports to advanced robotics, exoskeletons, and brain‐computer interface systems. While these technologies show promise for improving enabling function, current evidence is largely limited to ...
Katherine M. Burke +13 more
wiley +1 more source
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
eLife, 2019 The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B ...
Yao Liang Wong +21 more
doaj +1 more source
Emergencies in Amyotrophic Lateral Sclerosis
Muscle &Nerve, EarlyView.ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal +9 more
wiley +1 more source