Results 41 to 50 of about 6,896 (176)

A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

eLife, 2021
Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance of ...
Madhuja Samaddar, Jérôme Goudeau, Melissa Sanchez, David H Hall, K Adam Bohnert, Maria Ingaramo, Cynthia Kenyon   +6 more
doaj   +1 more source

Validation of the Telephone MoCA in iRBD and Parkinson's Disease with Conversion to the Standard MoCA

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Telephone‐based cognitive assessment may improve follow‐up when face‐to‐face testing is impractical. The Telephone Montreal Cognitive Assessment (T‐MoCA) omits visually dependent items from the standard MoCA, but its validity in isolated REM sleep behavior disorder (iRBD) and Parkinson's disease (PD), remains uncertain.
Ludo van Hillegondsberg, Tanja Zerenner, Michael Lawton, Karolien Groenewald, Jamil Razzaque, Jessica Welch, Yoav Ben‐Shlomo, Michele Hu   +7 more
wiley   +1 more source

Calico claims

, 2022
Scale not given.Photocopy.Shows Calico claims and pegmatite dike.Blackline print.Three-hole punched.Location diagram showing ...
Hillis, Don
core  

Chitosan and nano-TiO coating improves the flame retardancy of dyed and undyed denim fabrics by increasing the charring

Journal of Industrial Textiles, 2022
In this study, chitosan is obtained from the waste shells of crayfish ( Astacus leptodactylus ) and characterized. The crayfish chitosan was coated on cotton fabrics using the padding-drying method.
Nilgün Becenen, Sevil Erdoğan
doaj   +1 more source

Rare‐Variant Burden Analysis of Dystonia Genes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Dystonia frequently coexists with Parkinson's disease (PD), yet the extent of genetic overlap remains insufficiently explored. Objective The aim was to examine whether rare variants in dystonia‐related genes are associated with PD or early‐onset PD (EOPD).
Sajanth Kanagasingam, Sitki Cem Parlar, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +4 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby   +127 more
wiley   +1 more source

Association of ergonomics risk factors among Iranian calico crafts-men and musculoskeletal discomforts: a cross-sectional study

BMC Musculoskeletal Disorders, 2023
Background Work-related musculoskeletal disorders (WMSDs) have always been complaints reported by handicraft workers due to the repetitive and static nature of work.
Mahnaz Shakerian, Reza Esmaeili, Masoud Rismanchian   +2 more
doaj   +1 more source

Consistency of Serial Cerebrospinal Fluid α‐Synuclein Seed Amplification Assay Results in the Parkinson's Precision Medicine Initiative

Movement Disorders, EarlyView.
Abstract Background Studies reporting α‐synuclein seed amplification assay (aSyn‐SAA) results are often cross‐sectional. Objectives In this study, we investigated the intraindividual consistency of aSyn‐SAA results (Amprion) over time from participants in the Parkinson's Precision Medicine Initiative (PPMI).
David G. Coughlin, Caroline Gochanour, Jie Yin, Luis Concha‐Marambio, Carly Farris, Yihua Ma, David‐Erick Lafontant, Edwin Jabbari, Tanya Simuni, Ken Marek, Thomas F. Tropea, the Parkinson's Precision Medicine Initiative, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber   +77 more
wiley   +1 more source

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

eLife
Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation.
John Yong, Jacqueline E Villalta, Ngoc Vu, Matthew A Kukurugya, Niclas Olsson, Magdalena Preciado López, Julia R Lazzari-Dean, Kayley Hake, Fiona E McAllister, Bryson D Bennett, Calvin H Jan   +10 more
doaj   +1 more source

α‐Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Reliable biomarkers for Parkinson's disease (PD) pathology detection are essential for research. α‐Synuclein (aSyn) seed amplification assay (SAA) is a validated biomarker for misfolded aSyn. Objective The aim was to assess the association between aSyn SAA and LRRK2‐related PD (LRRK2‐PD) and its link to mitochondrial genetic burden.
Theresa Lüth, Carolin Gabbert, Teresa Kleinz, Christoph Much, Björn‐Hergen Laabs, Sebastian Sendel, Inke R. König, Amke Caliebe, Matthew Farrer, Brian Fiske, Cornelis Blauwendraat, Christine Klein, Joanne Trinh, Global Parkinson's Genetics Program (GP2)   +13 more
wiley   +1 more source