Results 21 to 30 of about 6,896 (176)

The genetic and biochemical determinants of mRNA degradation rates in mammals

Genome Biology, 2022
Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors governing it remain poorly characterized. Understanding the genetic and biochemical determinants of mRNA half-life would enable more precise identification of ...
Vikram Agarwal, David R. Kelley
doaj   +1 more source

Global patterns of prognostic biomarkers across disease space

Scientific Reports, 2022
There is a multitude of pathological conditions that affect human health, yet we currently lack a predictive model for most diseases, and underlying mechanisms that are shared by multiple diseases are poorly understood.
Neha Murad, Eugene Melamud
doaj   +1 more source

MAVEN2: An Updated Open-Source Mass Spectrometry Exploration Platform

Metabolites, 2022
MAVEN, an open-source software program for analysis of LC-MS metabolomics data, was originally released in 2010. As mass spectrometry has advanced in the intervening years, MAVEN has been periodically updated to reflect this advancement.
Phillip Seitzer, Bryson Bennett, Eugene Melamud   +2 more
doaj   +1 more source

A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

eLife, 2018
Replicative aging of Saccharomyces cerevisiae is an established model system for eukaryotic cellular aging. A limitation in yeast lifespan studies has been the difficulty of separating old cells from young cells in large quantities.
David G Hendrickson, Ilya Soifer, Bernd J Wranik, Griffin Kim, Michael Robles, Patrick A Gibney, R Scott McIsaac   +6 more
doaj   +1 more source

Structure of the p53 degradation complex from HPV16

Nature Communications
Human papillomavirus (HPV) is a significant contributor to the global cancer burden, and its carcinogenic activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase E6AP, also known as UBE3A, to promote ...
John C. K. Wang, Hannah T. Baddock, Amirhossein Mafi, Ian T. Foe, Matthew Bratkowski, Ting-Yu Lin, Zena D. Jensvold, Magdalena Preciado López, David Stokoe, Dan Eaton, Qi Hao, Aaron H. Nile   +11 more
doaj   +1 more source

Mathematical Modeling and Sensitivity Analysis of the Existence of Male Calico Cats Population Based on Cross Breeding of All Coat Colour Types

Communication in Biomathematical Sciences, 2019
The coat color of cats is normally governed by genes found on the X chromosome in both male chromosome XY and female chromosome XX. The meiosis failure in the process of gametogenesis leads to the birth of three-colored male cats caused by an excess of ...
Dani Suandi, Ira Prapti Ningrum, Amalia Nur Alifah, Nurul Izzah, Mazi Prima Reza, Imroatul Khoiriyah Muwahidah   +5 more
doaj   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis

Nature Communications
The integrated stress response (ISR) enables cells to cope with a variety of insults, but its specific contribution to downstream cellular outputs remains unclear.
Katherine Labbé, Lauren LeBon, Bryan King, Ngoc Vu, Emily H. Stoops, Nina Ly, Austin E. Y. T. Lefebvre, Phillip Seitzer, Swathi Krishnan, Jin-Mi Heo, Bryson Bennett, Carmela Sidrauski   +11 more
doaj   +1 more source

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

eLife, 2019
Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector ...
Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne JG Chan, Samir Kharbanda, Jonathon J O'Brien, Fiona E McAllister, Ari J Firestone, Calvin H Jan, Jeffrey Settleman   +9 more
doaj   +1 more source

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source