Results 11 to 20 of about 6,896 (176)
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nature Communications, 2022 PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide
Russell A. Judge +17 more
doaj +1 more source
Sugar phosphate activation of the stress sensor eIF2B
Nature Communications, 2021 The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between ...
Qi Hao +12 more
doaj +1 more source
Calico Bill and the Calico Madams: Fashion, Print, and the Public [PDF]
, 2021 Calico Bill and the Calico Madams: Fashion, Print, and the ...
Huck, Christian
core +1 more source
Nature Communications, 2023 Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and epidemiological etiology of this condition is not well understood.
Anurag Sethi +4 more
doaj +1 more source
Individual cell types in C. elegans age differently and activate distinct cell-protective responses
Cell Reports, 2023 Summary: Aging is characterized by a global decline in physiological function. However, by constructing a complete single-cell gene expression atlas, we find that Caenorhabditis elegans aging is not random in nature but instead is characterized by ...
Antoine Emile Roux +6 more
doaj +1 more source
Архитектон, 2022 St. Petersburg print ornaments occupy an important place in the context of Russian and European history of applied art. Today, many an art critic engage in printed textile studies, which makes this work relevant and modern.
Romanov Dmitry V.
doaj +1 more source
Learning causal networks using inducible transcription factors and transcriptome‐wide time series
Molecular Systems Biology, 2020 We present IDEA (the Induction Dynamics gene Expression Atlas), a dataset constructed by independently inducing hundreds of transcription factors (TFs) and measuring timecourses of the resulting gene expression responses in budding yeast. Each experiment
Sean R Hackett +9 more
doaj +1 more source
The diverse growth of 18th-century Catalonia: Proto-industrialisation? [PDF]
Catalan Historical Review, 2012 The concept of proto-industrialisation was useful for examining economic activities in many areas prior to the onset of industrialisation. In Catalonia, it was used to spotlight the wool industry and other activities and to separate it from what was ...
Llorenç Ferrer
doaj +1 more source
Age and diet shape the genetic architecture of body weight in diversity outbred mice
eLife, 2022 Understanding how genetic variation shapes a complex trait relies on accurately quantifying both the additive genetic and genotype–environment interaction effects in an age-dependent manner. We used a linear mixed model to quantify diet-dependent genetic
Kevin M Wright +6 more
doaj +1 more source
Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice
eLife, 2022 Behavior and physiology are essential readouts in many studies but have not benefited from the high-dimensional data revolution that has transformed molecular and cellular phenotyping.
Zhenghao Chen +8 more
doaj +1 more source