Results 1 to 10 of about 193,718 (292)
Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII. [PDF]
PLoS ONE, 2012 Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Melanie I Stefan +2 more
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Two distinct calmodulin binding sites in the third intracellular loop and carboxyl tail of angiotensin II (AT(1A)) receptor. [PDF]
PLoS ONE, 2013 In this study, we present data that support the presence of two distinct calmodulin binding sites within the angiotensin II receptor (AT(1A)), at juxtamembrane regions of the N-terminus of the third intracellular loop (i3, amino acids 214-231) and ...
Renwen Zhang +4 more
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Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. [PDF]
PLoS ONE, 2012 Calcium entry and the subsequent activation of CaMKII trigger synaptic plasticity in many brain regions. The induction of long-term potentiation (LTP) in the CA1 region of the hippocampus requires a relatively high amount of calcium-calmodulin.
Ling Zhong, Nashaat Z Gerges
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Human Calmodulin Mutations [PDF]
Frontiers in Molecular Neuroscience, 2018 Fluxes of calcium (Ca2+) across cell membranes enable fast cellular responses. Calmodulin (CaM) senses local changes in Ca2+ concentration and relays the information to numerous interaction partners. The critical role of accurate Ca2+ signaling on cellular function is underscored by the fact that there are three independent CaM genes (CALM1-3) in the ...
Jensen, Helene H +3 more
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Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases
BMC Neuroscience, 2022 Calcium dysregulation (“Calcium Hypothesis”) is an early and critical event in Alzheimer’s and other neurodegenerative diseases. Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred ...
Danton H. O’Day, Robert J. Huber
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Calmodulin adopts an extended conformation when interacting with L-selectin in membranes. [PDF]
PLoS ONE, 2013 Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear.
Wei Deng, John A Putkey, Renhao Li
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A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. [PDF]
PLoS ONE, 2013 All subtypes of KCNQ channel subunits (KCNQ1-5) require calmodulin as a co-factor for functional channels. It has been demonstrated that calmodulin plays a critical role in KCNQ channel trafficking as well as calcium-mediated current modulation. However,
Anastasia Kosenko, Naoto Hoshi
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Biomolecules, 2022 Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity ...
Matthew D. McCoy +3 more
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Calmodulin-Binding Protein Detection Using a Non-Radiolabeled Calmodulin Fusion Protein
BioTechniques, 2001 Calmodulin-binding proteins are involved in numerous cellular signaling pathways. The biotinylated-calmodulin overlay is a nonradioactive method widely used to detect calmodulin-binding proteins in tissue and cell samples.
Gloria Murray +3 more
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Plant Signaling & Behavior, 2022 Calmodulin (CaM) and calmodulin-like (CML) genes are widely involved in plant growth and development and mediating plant stress tolerance. However, the whole genome scale studies about CaM and CML gene families have not been done in wheat, and the ...
Yongwei Liu +14 more
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