Evolutionary Covariant Positions within Calmodulin EF-hand Sequences Promote Ligand Binding [PDF]
, 2018 Intracellular calcium signaling is an essential regulatory mechanism through calcium-mediated signal transduction pathways involved in many cell processes, such as exocytosis, motility, apoptosis, excitability, transcription, and muscle contraction.
Vaidyanathan, Uma
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Fishes, 2023 High environmental hydrogen peroxide (H2O2) has been demonstrated to be toxic for fish. However, the response mechanism of fish to chronic H2O2 exposure is not yet well understood.
Yating Mou +4 more
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Interactions of Calmodulin With the Multiple Binding Sites of Cav1.2 Ca2+ Channels
Journal of Pharmacological Sciences, 2010 Although calmodulin binding to various sites of the Cav1.2 Ca2+ channel has been reported, the mechanism of the interaction is not fully understood. In this study we examined calmodulin binding to fragment channel peptides using a semi-quantitative pull ...
Hadhimulya Asmara +3 more
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BMC Microbiology, 2007 Background Sporothrix schenckii is a pathogenic, dimorphic fungus, the etiological agent of sporotrichosis, a subcutaneous lymphatic mycosis. Dimorphism in S.
Rodriguez-del Valle Nuri +3 more
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Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]
, 2010 Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Bito, Haruhiko +5 more
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Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior
Antioxidants, 2018 Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown.
Méry Marimoutou +4 more
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Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation [PDF]
, 2005 The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been ...
Buffone, Mariano Gabriel +6 more
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CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]
, 2014 Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
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Neurogranin Regulates Metaplasticity
Frontiers in Molecular Neuroscience, 2020 Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory.
Ling Zhong, Nashaat Z. Gerges
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The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]
, 1990 The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian +3 more
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