Results 51 to 60 of about 193,718 (292)

Alzheimer’s Disease beyond Calcium Dysregulation: The Complex Interplay between Calmodulin, Calmodulin-Binding Proteins and Amyloid Beta from Disease Onset through Progression

Current Issues in Molecular Biology, 2023
A multifactorial syndrome, Alzheimer’s disease is the main cause of dementia, but there is no existing therapy to prevent it or stop its progression. One of the earliest events of Alzheimer’s disease is the disruption of calcium homeostasis but that is ...
Danton H. O’Day
doaj   +1 more source

Deduced Primary Structure of the β Subunit of Brain Type II Ca2+/calmodulin-dependent Protein Kinase Determined by Molecular Cloning [PDF]

, 1987
cDNA clones coding for the β subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region, hybridize at high stringency to a single band of poly(A)+ RNA ...
Bennett, Mark K., Kennedy, Mary B.
core  

Mechanical Stretching of Proteins: Calmodulin and Titin

, 2004
Mechanical unfolding of several domains of calmodulin and titin is studied using a Go-like model with a realistic contact map and Lennard-Jones contact interactions.
Abe, Banavar, Bernstein, Bockelmann, Carrion-Vasquez, Carrion-Vazquez, Carrion-Vazquez, Cieplak, Cieplak, Cieplak, Cieplak, Cieplak, Cieplak, Cluzel, Du, Florin, Fowler, Grubmuller, Guan, Hoang, Hoang, Improta, Janovjak, Kellermayer, Lu, Marek Cieplak, Maritan, Marszalek, Micheletti, Plaxco, Plaxco, Rief, Settanni, Smith, Takada, Tsai, Tskhovrebova, Unger, Veitshans, Yang   +39 more
core   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Piezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic Pressure via. CaM/Src/Pitx2 Activation in Atrial Myocytes

Frontiers in Cardiovascular Medicine, 2022
Hypertension is a major cardiovascular risk factor for atrial fibrillation (AF) worldwide. However, the role of mechanical stress caused by hypertension on downregulating the L-type calcium current (ICa,L), which is vital for AF occurrence, remains ...
Yuan Fang, Yuan Fang, Qian Li, Qian Li, Xin Li, Xin Li, Guan-Hao Luo, Guan-Hao Luo, Su-Juan Kuang, Su-Juan Kuang, Xue-Shan Luo, Xue-Shan Luo, Qiao-Qiao Li, Qiao-Qiao Li, Hui Yang, Hui Yang, Yang Liu, Yang Liu, Chun-Yu Deng, Chun-Yu Deng, Yu-Mei Xue, Yu-Mei Xue, Shu-Lin Wu, Shu-Lin Wu, Fang Rao, Fang Rao   +25 more
doaj   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Light‐Driven Competitive Selection in a Protein‐Catalyzed Dissipative Peptide Replication

Angewandte Chemie, EarlyView.
A structurally flexible protein catalyzes replication within a dissipative reaction network driven by UVA‐induced disulfide rearrangements. The protein accelerates templated autocatalytic cycles with replication emerging as the dominant pathway.
Éva Bartus, Edit Wéber, Attila Tököli, Ferenc Bogár, Momen R. F. Mohamed, Gábor Kecskeméti, Zoltán Szabó, Zoltán Kele, András Perczel, Márton Gadanecz, Zoltán Orgován, György M. Keserű, Tamás A. Martinek   +12 more
wiley   +2 more sources

Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1

Physiological Reports, 2018
Calmodulin (CaM) and S100A1 fine‐tune skeletal muscle Ca2+ release via opposite modulation of the ryanodine receptor type 1 (RyR1). Binding to and modulation of RyR1 by CaM and S100A1 occurs predominantly at the region ranging from amino acid residue ...
Erick O. Hernández‐Ochoa, Zephan Melville, Camilo Vanegas, Kristen M. Varney, Paul T. Wilder, Werner Melzer, David J. Weber, Martin F. Schneider   +7 more
doaj   +1 more source

An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors

Frontiers in Molecular Neuroscience, 2019
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention.
Eli J. Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortes, Matthew Florence, Nina S. Levy, Rachel Moss, Randall S. Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George K. E. Umanah, Andrew P. Levy   +16 more
doaj   +1 more source