Results 191 to 200 of about 21,266,386 (226)
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease. [PDF]
Hum Mol Genet, 2020 Weber JJ +7 more
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Triple-Negative Breast Cancer, Cisplatin and Calpain-1
, 2018 Shadia Al-Bahlani, Samiya Al-Jaaidi
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Role of calpain-1 in the early phase of experimental ALS
Archives of Biochemistry and Biophysics, 2014 Elevation in [Ca(2+)]i and activation of calpain-1 occur in central nervous system of SOD1(G93A) transgenic mice model of amyotrophic lateral sclerosis (ALS), but few data are available about the early stage of ALS. We here investigated the level of activation of the Ca(2+)-dependent protease calpain-1 in spinal cord of SOD1(G93A) mice to ascertain a ...
R. Stifanese +9 more
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The FEBS Journal, 2005
Calpain 1, a ubiquitous calcium‐dependent intracellular protease, was recently found in a tight association with myofibrils in skeletal muscle tissue [Delgado EF, Geesink GH, Marchello JA, Goll DE & Koohmaraie M (2001) J Anim Sci79, 2097–2107). Our immunofluorescence and immunoelectron microscopy investigations restrain the protease location at the
Raynaud, F. +8 more
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Calpain 1, a ubiquitous calcium‐dependent intracellular protease, was recently found in a tight association with myofibrils in skeletal muscle tissue [Delgado EF, Geesink GH, Marchello JA, Goll DE & Koohmaraie M (2001) J Anim Sci79, 2097–2107). Our immunofluorescence and immunoelectron microscopy investigations restrain the protease location at the
Raynaud, F. +8 more
openaire +5 more sources
Calpain-1-sensitive myofibrillar proteins of the human myocardium
Molecular and Cellular Biochemistry, 2005Calpain-1 is a ubiquitous intracellular Ca2+-activated protease, which has been implicated in the pathogenesis of reversible myocardial depression (i.e. myocardial stunning) that follows ischemia and reperfusion via myofibrillar protein degradation.
Judit, Barta +6 more
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Inhibition of motility by NEO100 through the calpain-1/RhoA pathway
Journal of Neurosurgery, 2020OBJECTIVEGlioblastoma (GBM) is the most aggressive type of brain tumor with a high rate of tumor recurrence, and it often develops resistance over time to current standard of care chemotherapy. Its highly invasive nature plays an essential role in tumor progression and recurrence.
Nagore I, Marín-Ramos +7 more
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Casein Zymography for Analysis of Calpain-1 and Calpain-2 Activity
2019Casein zymography is used to detect calpain activity in cell or tissue lysates. In this technique, lysates are loaded into a polyacrylamide gel containing casein, and the enzymes within the lysates are electrophoretically separated. The casein embedded in the gel acts as a substrate for calpains in the lysates, and its degradation reflects the activity
Ashim Kumar, Biswas, Samarth, Tandon
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Effect of nitric oxide on myofibrillar proteins and the susceptibility to calpain-1 proteolysis
Food Chemistry, 2019This study was designed to investigate the nature of modification of myofibrillar proteins by nitric oxide (NO) and the extent to which S-nitrosylation alters their susceptibility to calpain-1 proteolysis. Isolated myofibrils from porcine semimembranosus muscle were incubated with the NO donor S-nitrosoglutathione (GSNO) at 0, 20, 50, 250, 1000 µM for ...
Rui Liu +5 more
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Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells
Biochemical Journal, 2019Abstract Hepsin is a transmembrane serine protease implicated in many biological processes, including hepatocyte growth, urinary protein secretion, auditory nerve development, and cancer metastasis. Zymogen activation is critical for hepsin function. To date, how hepsin is activated and regulated in cells remains an enigma. In this study,
Lina Wang +8 more
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