Results 201 to 210 of about 21,266,386 (226)

Calpain-1 Inhibitors for Selective Treatment of Rheumatoid Arthritis: What is the Future?

Future Medicinal Chemistry, 2013
Effective small-molecule treatment of inflammatory diseases remains an unmet need in medicine. Current treatments are either limited in effectiveness or invasive. The latest biologics prevent influx of inflammatory cells to damaged tissue. Calpain-1 is a calcium-activated cysteine protease that plays an important role in neutrophil motility.
David J, Miller, Sarah E, Adams, Maurice B, Hallett, Rudolf K, Allemann   +3 more
openaire   +2 more sources

Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease

Journal of Alzheimer's Disease, 2015
Alzheimer’s disease, one of the most important brain pathologies associated with neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis. Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic plasticity and memory produced by the excess of amyloid-β, a distinctive marker of the ...
Mauro, Fà, Hong, Zhang, Agnieszka, Staniszewski, Faisal, Saeed, Li W, Shen, Isaac T, Schiefer, Marton I, Siklos, Subhasish, Tapadar, Vladislav A, Litosh, Jenny, Libien, Pavel A, Petukhov, Andrew F, Teich, Gregory R J, Thatcher, Ottavio, Arancio   +13 more
openaire   +2 more sources

Localization of calpain 1 within mitochondria

Mitochondrion, 2015
Qun Chen, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky   +3 more
openaire   +1 more source

μ-Calpain oxidation and proteolytic changes on myofibrillar proteins from Coregonus Peled in vitro

Food Chemistry, 2021
Zhiwei Zhang, Xiaobing Guo, Xinrong Zhu   +2 more
exaly  

P1‐220: SELECTIVE CALPAIN‐1 VERSUS CALPAIN‐1/CATHEPSIN‐B DUAL INHIBITION AS A THERAPEUTIC APPROACH TO AD

Alzheimer's & Dementia, 2018
Rachel C. Knopp, Manel Ben Aissa, Ammar Jastinah, Sue H. Lee, Ragda Izar   +4 more
openaire   +1 more source

Calpain-1/μ-Calpain

2013
Hiroyuki Sorimachi, Shoji Hata, Yasuko Ono   +2 more
openaire   +1 more source

Calpain-1

2009
openaire   +1 more source

Calpain research for drug discovery: challenges and potential

Nature Reviews Drug Discovery, 2016
Yasuko Ono, Takaomi C Saido, Hiroyuki Sorimachi   +2 more
exaly  

The calpain family and human disease

Trends in Molecular Medicine, 2001
Kevin K W Wang
exaly  

Cardiac injury: Role of mitochondrial calpain 1 activation

Mitochondrion, 2015
Jeremy Thompson, Ying Hu, Edward J. Lesnefsky, Qun Chen   +3 more
openaire   +1 more source