Results 101 to 110 of about 26,568 (204)
Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres +2 more
wiley +1 more source
Measuring Calpain 3 Proteolytic Activity Using an in vitro Substrate
Neuromuscular disorders, 2006 Limb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive muscular disorder caused by mutations in the gene coding for calpain 3, a calcium-dependent protease. In order to improve LGMD2A diagnosis, we have developed an in vitro assay that can detect the proteolytic activity of calpain 3 in a muscle sample. This assay is based on the use
N. Daniele +9 more
openaire +4 more sources
Auditory Stimulation of Slow‐Wave Sleep Promotes Recovery after Brain Injury in an Animal Model
Annals of Neurology, Volume 100, Issue 2, Page 242-254, August 2026.Objective Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available.
Carlos G. Moreira +9 more
wiley +1 more source
Frontiers in OncologyIntroductionGlioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis.
Laura Guarnaccia +20 more
doaj +1 more source
Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related. [PDF]
Int J Mol Sci, 2021 Rico A +8 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.This study found that human umbilical cord mesenchymal stem cells secrete β‐NGF, which binds to the TrkA receptor on neurons, upregulates the protein levels of STMN2 and NMNAT2 in mice with perioperative neurocognitive disorders, and thereby downregulates the protein levels of SARM1 and p‐NF‐κB.
Kai Wang +9 more
wiley +1 more source
Targeted Next-Generation Sequencing Reveals Mutations in Non-coding Regions and Potential Regulatory Sequences of Calpain-3 Gene in Polish Limb-Girdle Muscular Dystrophy Patients. [PDF]
Front Neurosci, 2021 Macias A +5 more
europepmc +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Schematic diagram of the manufacturing process of exosomes‐cardiac homing peptide (Exo‐CHP) and its therapeutic effects for Duchenne muscular dystrophy (DMD) cardiomyopathy. Abstract Background Duchenne muscular dystrophy (DMD)‐associated cardiomyopathy is a leading causes of premature death, yet treatment options remain limited.
Qihong Wu +13 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 8, August 2026.Coastal development can alter the salinity fluctuations experienced by tidal creek systems. Understanding how resident organisms, such as the Gulf killifish, respond to these changes is critical, as development along the coastline is projected to triple in the coming decades.
Antrelle D. Clark +3 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source