Results 101 to 110 of about 28,592 (236)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Determination of autolysis of calpain-3 in lens in homogenates of βA3cKO and wild-type lenses by western blot analysis.

, 2023
(A) The Calpain-3 activity was assessed by determining the ratio of total calpain-3 protein (the intensity of full length calpain 3 band + intensity of cleaved fragments) to the amount of uncleaved full-length calpain-3 (intensity of full length calpain ...
Laura Lambert (10683666), Roy Joseph (152104), Om P. Srivastava (14856987), Michael L. Robinson (14856984)   +3 more
core   +1 more source

Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy

The FEBS Journal, EarlyView.
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck, Lukas David Landegger   +1 more
wiley   +1 more source

Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered

Respiratory Research, 2010
Background High dose of corticosteroids has been previously shown to protect against controlled mechanical ventilation (CMV)-induced diaphragmatic dysfunction while inhibiting calpain activation.
Decramer Marc, Powers Scott K, Smuder Ashley, Agten Anouk, Maes Karen, Gayan-Ramirez Ghislaine   +5 more
doaj   +1 more source

Proteolysis of tau by calpain

, 1989
The calpain-induced proteolysis of tau associated with twice-cycled microtubules or from a total brain heat-stable fraction was studied. Twice-cycled microtubule tau was rapidly hydrolyzed by calpain.
Johnson, Gail V.W, Jope, Richard S, Binder, Lester I   +2 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor

Neurobiology of Disease, 2012
To describe how a high fat diet (HFD) and hyperglycemia initiate a sequence of calpain activation and oxidative stress associated with neuro-degenerative changes in diabetic retinopathy (DR), hyperglycemia was induced with streptozotocin in mice lacking ...
Ahmed Y. Shanab, Toru Nakazawa, Morin Ryu, Yuji Tanaka, Noriko Himori, Keiko Taguchi, Masayuki Yasuda, Ryo Watanabe, Jiro Takano, Takaomi Saido, Naoko Minegishi, Toshio Miyata, Toshiaki Abe, Masayuki Yamamoto   +13 more
doaj   +1 more source

Validation of 14-3-3η and calpain 2.

, 2013
Western Blot analysis of 14-3-3η showed decreased abundance (A) in HFD rats. (B) DAB staining revealed 14-3-3η in both, the urothelium und rBSMC. (C-E) Analysis of calpain 2 showed down-regulation of calpain 2 expression (C) and calpain 1/2 activity (D ...
Jochen Neuhaus (152170), Volker Adams (107823), Holger Till (152165), Nico Jehmlich (425790), Marco Heinrich (152162), Henry Wirth (128521), Nadine Schlichting (152159), Jens-Uwe Stolzenburg (152168), Stefanie Lehmann (425791), Uwe Völker (112748), Andreas Oberbach (107803)   +10 more
core   +1 more source

Transcriptomic profiling of gill biopsies to define predictive markers for seawater survival in farmed Atlantic salmon

Journal of Fish Biology, EarlyView.
Abstract Wild Atlantic salmon migrate to sea following completion of a developmental process known as parr‐smolt transformation (PST), which establishes a seawater (SW) tolerant phenotype. Effective imitation of this aspect of anadromous life history is a crucial aspect of commercial salmon production, with current industry practice being marred by ...
Lars Grønvold, Mattis J. van Dalum, Anja Striberny, Domniki Manousi, Trine Ytrestøyl, Turid Mørkøre, Solomon Boison, Bjarne Gjerde, Even Jørgensen, Simen R. Sandve, David G. Hazlerigg   +10 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source