Results 121 to 130 of about 28,592 (236)
, 2000 Calpains play important roles in numerous physiological and pathological processes (1,2) by catalyzing the limited proteolysis of a wide variety of protein substrates.
Guttmann, Rodney P. (author) +1 more
core
Muscle pathology in 31 patients with calpain 3 gene mutations
Neurologia i Neurochirurgia Polska, 2013 At present, more than 20 different forms of limb-girdle muscular dystrophies (LGMDs) are known (at least 7 autosomal dominant and 14 autosomal recessive). Although these different forms show some typical phenotypic characteristics, the existing clinical overlap makes their differential diagnosis difficult. Limb-girdle muscular dystrophy type 2 (LGMD2A)
Aleksandra A, Nadaj-Pakleza +5 more
openaire +3 more sources
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman +2 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 2005 The limb-girdle muscle dystrophy (LGMD) represents a heterogeneous group of muscular diseases with dominant and recessive inheritance, individualized by gene mutation.
Enio Alberto Comerlato +2 more
doaj +1 more source
Family and literature analysis demonstrates phenotypic effect of two variants in the calpain-3 gene. [PDF]
Neurogenetics, 2023 Tomforde M +3 more
europepmc +1 more source
Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem +2 more
wiley +1 more source
Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation. [PDF]
Int J Mol Sci, 2023 Wette SG, Lamb GD, Murphy RM.
europepmc +1 more source
$In\ Vivo$ Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration
, 2003 International audienceThe role of caspases and calpains in neurodegeneration remains unclear. In this study, we focused on these proteases in a rat model of Huntington's disease using the mitochondrial toxin 3-nitropropionic acid (3NP).
Escartin, Carole +9 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.
, 2004 In the absence and in the resolution of inflammatory responses, neutrophils rapidly undergo spontaneous apoptosis. Here we report about a new apoptosis pathway in these cells that requires calpain-1 activation and is essential for the enzymatic ...
Conus S. +4 more
core +1 more source