Results 141 to 150 of about 28,592 (236)

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Targeted Next-Generation Sequencing Reveals Mutations in Non-coding Regions and Potential Regulatory Sequences of Calpain-3 Gene in Polish Limb-Girdle Muscular Dystrophy Patients. [PDF]

Front Neurosci, 2021
Macias A, Fichna JP, Topolewska M, Rȩdowicz MJ, Kaminska AM, Kostera-Pruszczyk A.   +5 more
europepmc   +1 more source

The role of Calpain 3 in sheep skeletal muscle growth and post-mortem meat quality

, 2014
Calpain 3 is a tissue specific calpain, and its mRNA is the most expressed calpain isoform in skeletal muscles. Many mutations and polymorphisms within the human calpain 3 gene have been reported and related to limb-girdle muscular dystrophy.
Muto, Yukiyo
core  

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Interaction between calpain and HSP90.

, 2015
(A) Purified calpain-1 or-2 (1.5 µg) was incubated for 1 hour at 25°C with the indicated amounts of purified HSP90. Immunoprecipitation was carried out using 1 µg of anti-HSP90 antibody.
Sandro Pontremoli (309270), Monica Averna (164404), Franca Salamino (309263), Marco Pedrazzi (309260), Margherita Bavestrello (682815), Edon Melloni (164418), Matteo Pellegrini (2078), Roberta De Tullio (365362)   +7 more
core   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Ryanodine Receptor Ca2+ Leak‐Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The dystrophic mdx mouse is a widely used model of Duchenne muscular dystrophy. Altered Ca2+ handling is a key feature, including increased Ca2+ leak through the ryanodine receptor (RyR1's), the primary Ca2+ release channel in skeletal muscle. Such leak has important downstream consequences for intracellular Ca2+ homeostasis.
Rhayanna B. Gaglianone, Cedric R. Lamboley, Taylor Dick, Aldo Meizoso‐Huesca, Daniel P. Singh, Bradley S. Launikonis   +5 more
wiley   +1 more source

Copy Number Variation in Native and Crossbred Pigs Provides Insights Into Genomic Consequences of Domestication

Molecular Ecology, Volume 35, Issue 11, June 2026.
ABSTRACT Sus scrofa has been domesticated under diverse environments and management systems, leading to broad variation in genetic architecture and physiological regulation. This diversity has been preserved in indigenous breeds maintained under traditional husbandry and further expanded through modern crossbreeding programs designed to combine the ...
Bongsang Kim, Jeongwoo Seo, Heebal Kim, Young‐Sin Kim, Jongan Lee, Seoae Cho   +5 more
wiley   +1 more source

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

A third of LGMD2A biopsies have normal calpain 3 proteolytic activity as determined by an in vitro assay

, 2007
International audienceLimb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive muscular disorder caused by mutations in the gene coding for calpain 3, a calcium-dependent protease.
M. Moggio, G.P. Comi, Bartoli, Marc, Poupiot, Jérôme, C. Roudaut, Comi, Giacomo P., I. Richard, Lochmueller, Hanns, Walter, Maggie C., M. Mora, R. E. Bittner, Morandi, Lucia, Bittner, Reginald E., Milic, Astrid, A. Milic, Mora, Marina, Moggio, Maurizio, Roudaut, Carinne, Richard, Isabelle, Danièle, Nathalie, M. Bartoli, H. Lochmüller, M. C. Walter, Noulet, Fanny, J. Poupiot, N. Daniele, L. Morandi, F. Noulet   +27 more
core   +1 more source