Results 131 to 140 of about 28,592 (236)

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1129-1140, June 2026.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening. [PDF]

Int J Mol Sci, 2021
Baburuna Y, Sotnikova L, Krestinina O.
europepmc   +1 more source

Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial injury?

, 2003
Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial injury?BackgroundThe cysteine proteases calpain and caspase-3 are known mediators of cell death. The aim of this study was to assess their contribution to the
Alistair M.S. Chesser, Harwood, Steven M., Allen, David A., Yaqoob, Muhammad M., Martin J. Raftery, David I. New, New, David I., David A. Allen, Chesser, Alistair M.S., Steven M. Harwood, Raftery, Martin J., Muhammad M. Yaqoob   +11 more
core   +1 more source

Measuring Calpain 3 Proteolytic Activity Using an in vitro Substrate

Neuromuscular disorders, 2006
Limb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive muscular disorder caused by mutations in the gene coding for calpain 3, a calcium-dependent protease. In order to improve LGMD2A diagnosis, we have developed an in vitro assay that can detect the proteolytic activity of calpain 3 in a muscle sample. This assay is based on the use
N. Daniele, A. Milic, M. Bartoli, H. Lochmueller, M. Mora, G.P. COMI, M. MOGGIO, F. Noulet, J. Poupiot, I. Richard   +9 more
openaire   +4 more sources

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Selective pseudohypertrophy of vastus medialis muscles associated with calpain 3 deficiency.

, 2012
INTRODUCTION: Calpain 3 deficiency causes limb girdle muscular dystrophy type 2A, which is one of the most common forms of limb girdle muscular dystrophy.
MARINI, Matteo, BERTOLASI, LAURA, Novelli, G., VATTEMI, Gaetano Nicola, Neri, M., Catalli, C., Ferlini, A., TONIN, PAOLA, TOMELLERI, Giuliano, Gualandi, F., GUGLIELMI, Valeria   +10 more
core   +2 more sources

Testing calpain inhibition in tumor endothelial cells: novel targetable biomarkers against glioblastoma malignancy

Frontiers in Oncology
IntroductionGlioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis.
Laura Guarnaccia, Stefania Elena Navone, Laura Begani, Emanuela Barilla, Emanuele Garzia, Emanuele Garzia, Rolando Campanella, Monica Miozzo, Monica Miozzo, Laura Fontana, Laura Fontana, Giovanni Alotta, Chiara Cordiglieri, Chiara Gaudino, Luigi Schisano, Antonella Ampollini, Laura Riboni, Marco Locatelli, Marco Locatelli, Giovanni Marfia, Giovanni Marfia   +20 more
doaj   +1 more source

Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related. [PDF]

Int J Mol Sci, 2021
Rico A, Guembelzu G, Palomo V, Martínez A, Aiastui A, Casas-Fraile L, Valls A, López de Munain A, Sáenz A.   +8 more
europepmc   +1 more source

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

, 2008
g.oxfordjournals.org/ D ow nloaded from Calpain 3 is a non-lysosomal cysteine protease that is necessary for normal muscle function, as mutations in calpain 3 result in an autosomal recessive form of limb girdle muscular dystrophy type 2A (LGMD2A).
Spencer, Melissa J., Benjamin Wu, Ottenheijm, Coen, Henk Granzier, Melissa J. Spencer, Kudryashova, Elena, Kramerova, Irina, Granzier, Henk, Irina Kramerova, Elena Kudryashova, Coen Ottenheijm, Wu, Benjamin   +11 more
core   +1 more source