Results 81 to 90 of about 364 (107)

Synthesis and antimycobacterial activity of novel camphane-based agents

Bioorganic & Medicinal Chemistry Letters, 2014
A series of six new amidoalcohols was designed and synthesized on the base of the camphor scaffold. Natural amino acids were transformed into their α-hydroxy analogues with retention of configuration, and attached to isobornylamine. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv.
Georgi, Stavrakov, Irena, Philipova, Violeta, Valcheva, Georgi, Momekov   +3 more
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Design of novel camphane-based derivatives with antimycobacterial activity

Journal of Molecular Graphics and Modelling, 2014
Although tuberculosis (TB) continues to be one of the leading infectious disease killers globally, it is curable and preventable. Despite the existence of safe, well tolerated and effective drugs used in the TB treatment, the interest in new entities, combinations and regimens increases during the last 10 years. Recently, we reported for a new class of
Georgi, Stavrakov, Violeta, Valcheva, Irena, Philipova, Irini, Doytchinova   +3 more
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Robustadials. 3. Total synthesis of camphane analogs

The Journal of Organic Chemistry, 1988
A partir de trimethoxy-1,3,5 benzene et de camphenilane, synthese des 4 diastereoisomeres du diformyl-6,8 dimethoxy-5,7 dimethyl-3'3' isobutyl-4 spiro [chromanne-2:2'-norbornane]; ces composes ne sont pas des ...
Samuel M. Mazza, Kasturi Lal, Robert G. Salomon   +2 more
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Structure and absolute configuration of (E)-(–)-2-cyclododecenyl camphanate

Acta Crystallographica Section C Crystal Structure Communications, 1989
C22H34O4, Mr = 362.51, monoclinic, P2(1), a = 7.371 (1), b = 10.571 (1), c = 13.538 (2) A, beta = 90.36 (1) degree, V = 1054.84 A3, Z = 2, Dx = 1.141 Mg m-3, lambda(Cu K alpha) = 1.5418 A, mu = 0.577 mm-1, F(000) = 396, T = 296 K, R = 0.057 for 1550 unique reflections with I greater than or equal to sigma(I). The crystal conformation of the 12-membered
S, Ito, H, Ziffer, J V, Silverton
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Vibrational Absorption and Circular Dichroism Studies of (−)-Camphanic Acid

The Journal of Physical Chemistry A, 2007
Vibrational absorption and circular dichroism (VCD) spectra of (-)-(1S,3R)-camphanic acid have been measured in deuterated chloroform solutions at different concentrations (0.005, 0.045, and 0.200 M) in the mid-infrared spectral range. Experimental spectra have been compared with the density functional theory (DFT) absorption and VCD spectra ...
Thierry, Buffeteau, Dominique, Cavagnat, Aude, Bouchet, Thierry, Brotin   +3 more
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Novel camphane-based anti-tuberculosis agents with nanomolar activity

European Journal of Medicinal Chemistry, 2013
A series of new amidoalcohols and amidodiols were designed on the base of the camphor scaffold and evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv and MDR strain 43. Some of the new compounds show 25 times higher activity than the classical anti-TB drug ethambutol.
Georgi, Stavrakov, Violeta, Valcheva, Irena, Philipova, Irini, Doytchinova   +3 more
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ChemInform Abstract: A SYNTHETIC CANNABINOID WITH A CAMPHANE MOIETY

Chemischer Informationsdienst, 1976
AbstractDurch Bestrahlen von Cannabidiolsäure (I) in Cyclohexan in Gegenwart von Sauerstoff wird zusätzlich zu bekannten Verbindungen ein bisher unbekanntes Cannabinoid (II) mit einem Camphankern in geringer Menge erhalten.
J. K. KITANY, S. K. PAKNIKAR
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NMR Spectroscopic Study of Camphanic Acid, Rh₂[Camphanate]₄, and its Adducts with 1,4-Benzodiazepines

Spectroscopy Letters, 1995
Abstract The H and 13C NMR spectra of chiral camphanic acid, lactonc of (1S,3R)-1-hydroxy-2,2,3-trimethyl-cyclopentan-1,3-dicarboxylic acid (1), and dirhodium tetracamphanate complex (2) were completely assigned on the basis of one- and two-dimensional NMR experiments.
Branimir Klaić, Zlata Raza, Radovan Marčec, Vladimir Vinković, Vitomirš Unjić   +4 more
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CD SPECTRA OF DIASTEREOMERIC α-ARYLETHYLAMIDES OF (–)-CAMPHANIC ACID

Spectroscopy Letters, 2002
ABSTRACT CD spectra of diastereomeric α-arylethylamides 2,3, 4,5 and 6,7 exhibit nearly enantiomorphic CD curves. Interchromophoric charge-transfer interaction between the aromatic and the amide chromophore is observed only in the amide nπ* band region.
Zdenko Hameršak, Marin Roje, Miklòs Hollòsi, Zsuza Majer, Vitomir Šunjic   +4 more
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Synthesis of a sterically congested diazirine: 2-azi-camphane

Tetrahedron Letters, 1996
Abstract The synthesis of 2-azi-camphane has been achieved despite the fact that the spirocyclic carbon center is sterically congested. Although the yield is somewhat low, the highly pure diazirine can be used as a precursor for the burgeoning class of sterically congested carbenes.
René Kupfer, Murray G. Rosenberg, Udo H. Brinker   +2 more
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