Results 1 to 10 of about 43,494 (228)
Nature Communications, 2021 Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by ...
Rao Fu, Shangling Lou, Yang Chen
exaly +2 more sources
Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer [PDF]
Current Issues in Molecular BiologyBreast cancer is one of the leading causes of cancer-related mortality in women worldwide, highlighting the importance of effective therapies. This study evaluates the interaction between camptothecin, a potent anticancer agent, and two key receptors ...
Elmer Joel Millan-Casarrubias +5 more
doaj +2 more sources
ATM deficiency results in accumulation of DNA-Topoisomerase I covalent intermediates in neural cells [PDF]
, 2013 Accumulation of peptide-linked DNA breaks contributes to neurodegeration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1) and human hereditary ataxia.
Alagoz, Meryem +3 more
core +27 more sources
Molecules, 2022 Exploring the metabolic potency of fungi as camptothecin producers raises the hope of their usage as an industrial source of camptothecin, due to their short-life span and the feasibility of metabolic engineering.
Ashraf S. A. El-Sayed +7 more
doaj +1 more source
Scientific Reports, 2023 Camptothecin is an important anticancer alkaloid produced by particular plant species. No suitable synthetic route has been established for camptothecin production yet, imposing a stress on plant-based production systems. Endophytes associated with these
Shakunthala Natarajan +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment ...
Dongdong Yin +11 more
doaj +1 more source
Screening and selection of camptothecin producing endophytes from Nothapodytes nimmoniana
Scientific Reports, 2021 Endophytic fungi with the ability to produce plant based secondary metabolites are a potential alternative for producing the host plant metabolite and to prevent natural plants from extinction. To isolate a high metabolite yielding endophytic strain from
I. A. H. Khwajah Mohinudeen +4 more
doaj +1 more source
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives. [PDF]
PLoS ONE, 2011 Human topoisomerase I (Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death, and this makes Top1 an anti-cancer target.
Gary S Laco
doaj +1 more source
Microbial Cell Factories, 2023 The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production, however, the loss of camptothecin productivity by fungi with the storage and subculturing are the major obstacle ...
Ashraf S. A. El-Sayed +4 more
doaj +1 more source
Sustainable production of camptothecin from an Alternaria sp. isolated from Nothapodytes nimmoniana
Scientific Reports, 2021 Camptothecin the third most in demand alkaloid, is commercially extracted in India from the endangered plant, Nothapodytes nimmoniana. Endophytes, the microorganisms that reside within plants, are reported to have the ability to produce host–plant ...
I. A. H. Khwajah Mohinudeen +5 more
doaj +1 more source