Results 91 to 100 of about 43,494 (228)

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Molecules, 2019
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Effect of hydrogen bonding and complexation with metal ions on the fluorescence of luotonin A [PDF]

, 2013
Fluorescence characteristics of a biologically active natural alkaloid, luotonin A (LuA), were studied by steady-state and time-resolved spectroscopic methods.
Abraham, Abraham, Babu, Cagir, Carmona, Carmona, Cheng, Chou, Dallavalle, Dey, Dobkowski, Fung, Gonzalez-Ruiz, Gonzalez-Ruiz, Li, Liang, Lim, László Biczók, Ma, Maliakal, Marcus, Marcus, Marcus, Mason, Melhuish, Miskolczy, Miskolczy, Miskolczy, Miskolczy, Mussardo, Nagy, Nikolov, Peintler, Penedo, Reichardt, Reyman, Reyman, Sánchez-Coronilla, Takeuchi, Toele, Tseng, Vetokhina, Waluk, Yadav, Zhou, Zsombor Miskolczy   +45 more
core   +1 more source

Uptake of DPYD and UGT1A1 testing in Italy and adherence to pharmacogenetic guidelines: A 5‐year perspective from an EQA provider

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 445-456, February 2026.
Aims Pharmacogenetic implementation requires awareness of the state‐of‐the‐art practice of laboratories providing pharmacogenetic testing. This study investigated how pharmacogenetic guidelines and recommendations have been implemented over time by Italian laboratories participating in the external quality assessment (EQA) Pharmaco‐scheme established ...
Rossana Roncato, Samantha Perfler, Diletta Pasin, Elena Peruzzi, Michael Woodcock, Henry Thomas, Rebecca Goodall, Simon J. Patton, Erika Cecchin   +8 more
wiley   +1 more source

Dynamics of living cells in a cytomorphological state space. [PDF]

, 2019
Cells are nonequilibrium systems that exchange matter and energy with the environment to sustain their metabolic needs. The nonequilibrium nature of this system presents considerable challenges to developing a general theory describing its behavior ...
Chang, Amy Y, Marshall, Wallace F
core  

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors

Drug Delivery, 2017
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations ...
Casimiro Luca Gigliotti, Benedetta Ferrara, Sergio Occhipinti, Elena Boggio, Giuseppina Barrera, Stefania Pizzimenti, Mirella Giovarelli, Roberto Fantozzi, Annalisa Chiocchetti, Monica Argenziano, Nausicaa Clemente, Francesco Trotta, Caterina Marchiò, Laura Annaratone, Renzo Boldorini, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani   +17 more
doaj   +1 more source

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus [PDF]

, 2017
The PIDDosome (PIDD–RAIDD–caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD.
Ahmad, Ando, Andrew Oberst, Antoniali, Baliga, Baliga, Balusu, Bertwistle, Berube, Boatright, Bock, Bolli, Bonzon, Bouchier-Hayes, Bouchier-Hayes, Brittany A. Rohrman, Chloé I. Charendoff, Colombo, Colombo, Cullen, Dimitrova, Dorstyn, Duan, Falini, Grisendi, Grisendi, Gundry, Guo, Ho, Jang, Janssens, Janssens, Kaufmann, Kiyohiro Ando, Korgaonkar, Lassus, Lin, Lindström, Lisa Bouchier-Hayes, Mancini, Manzl, Manzl, Manzl, Melissa J. Parsons, Mitrea, Mitrea, Moreno-Mateos, Muzio, Myers, Nam, Oliver, O’Reilly, Pan, Park, Parsons, Peter H. Liu, Pianese, Puccini, Puccini, Qi, Richa B. Shah, Robertson, Ruth Thompson, Salvesen, Samuel Sidi, Sara R. Fassio, Sheré L. Paris, Shyu, Sidi, Terry, Thompson, Tinel, Tinel, Weber, Wejda   +74 more
core   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source