Results 111 to 120 of about 43,494 (228)

In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2

Biomolecules
Pro-drugs, which ideally release their active compound only at the site of action, i.e., in a cancer cell, are a promising approach towards an increased specificity and hence reduced side effects in chemotherapy.
Frank Beierlein, Anselm H. C. Horn, Heinrich Sticht, Andriy Mokhir, Petra Imhof   +4 more
doaj   +1 more source

Transcriptomic and proteomic profiling of maize embryos exposed to camptothecin

BMC Plant Biology, 2011
Background Camptothecin is a plant alkaloid that specifically binds topoisomerase I, inhibiting its activity and inducing double stranded breaks in DNA, activating the cell responses to DNA damage and, in response to severe treatments, triggering cell ...
Vicient Carlos M, García-Muniz Nora, Irar Sami, Sánchez-Pons Nuria   +3 more
doaj   +1 more source

Patent Disclosure and R&D Competition in Pharmaceuticals. [PDF]

The prominent role played by patents within the pharmaceutical domain is unquestionable. In this paper we take an unusual perspective and focus on a relatively neglected implication of patents: the effect of patent-induced information disclosure (of both
Fabio Pammolli, Laura Magazzini, Maria Alessandra Rossi, Massimo Riccaboni   +3 more
core   +3 more sources

Molecular and cellular effects of the combined treatment with Camptothecin and Roscovitine in human lung and colon adenocarcinoma cells [PDF]

, 2008
De Mattia, Roberta
core   +1 more source

Camptothecin: A promising antiretroviral drug

Journal of Biomedical Science, 1996
The plant alkaloid camptothecin (CPT) has demonstrated the ability to inhibit replication of the equine anemia virus (E1AV) and the human immunodeficiency virus (HIV) in infected cells in culture. Further, CPT prevented the development of lymphoma and erythroleukemia in mice infected with the Moloney murine leukemia virus and the Friend erythroleukemia
openaire   +2 more sources

High-Precision Field- Effect Transistor Biosensor for Analyzing Differential Effects of Anti-Cancer Drugs on Cancerous and Non-Cancerous Cells

Biosensors
A high-precision biosensor technique is introduced, offering the capability to independently evaluate the effects of anti-cancer drugs on both cancerous (RAJI) and non-cancerous (WIL2S) cells.
Can Li, Can Hu, Ling Li, Feng He, Xiaofei Li   +4 more
doaj   +1 more source

Future-Oriented Nanosystems Composed of Polyamidoamine Dendrimer and Biodegradable Polymers as an Anticancer Drug Carrier for Potential Targeted Treatment

Pharmaceutics
Background/Objectives: Camptothecin (CPT) is a well-known chemical compound recognized for its significant anticancer properties. However, its clinical application remains limited due to challenges related to CPT’s high hydrophobicity and the instability
Katarzyna Strzelecka, Adam Kasiński, Tadeusz Biela, Anita Bocho-Janiszewska, Anna Laskowska, Łukasz Szeleszczuk, Maciej Gawlak, Marcin Sobczak, Ewa Oledzka   +8 more
doaj   +1 more source

Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines. [PDF]

Chem Biodivers
Maistry L, Gerrano AS, Mellem JJ.
europepmc   +1 more source

Mechanistic role of CD82 palmitoylation in augmenting antitumor drug sensitivity via apoptosis regulation. [PDF]

Front Oncol
Li L, Yu Y, Chen S, Zhang Y, Zhang C, Yao X, Xu H, Wu S, Gong X, Han W, Zhang Y, Li Y.   +11 more
europepmc   +1 more source

Determination and Pharmacokinetic of Peiminine in Beagle Dogs by UPLC-MS/MS. [PDF]

Int J Anal Chem
Cheng Q, Peng X, Li X, Jia X.
europepmc   +1 more source