Results 11 to 20 of about 43,494 (228)

CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA. [PDF]

PLoS ONE, 2014
CFS-1686 (chemical name (E)-N-(2-(diethylamino)ethyl)-4-(2-(2-(5-nitrofuran-2-yl)vinyl)quinolin-4-ylamino)benzamide) inhibits cell proliferation and triggers late apoptosis in prostate cancer cell lines.
Ru-Wei Lin, Chia-Ning Yang, ShengYu Ku, Cheng-Jung Ho, Shih-Bo Huang, Min-Chi Yang, Hsin-Wen Chang, Chun-Mao Lin, Jaulang Hwang, Yeh-Long Chen, Cherg-Chyi Tzeng, Chihuei Wang   +11 more
doaj   +1 more source

Genome-wide transcriptional effects of the anti-cancer agent camptothecin. [PDF]

PLoS ONE, 2013
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex".
Artur Veloso, Benjamin Biewen, Michelle T Paulsen, Nathan Berg, Leonardo Carmo de Andrade Lima, Jayendra Prasad, Karan Bedi, Brian Magnuson, Thomas E Wilson, Mats Ljungman   +9 more
doaj   +1 more source

Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

Microbiology Spectrum, 2023
Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus
Amgad M. Rady, Ashraf S. A. El-Sayed, Ashraf F. El-Baz, Ghada G. Abdel-Fattah, Sameh Magdeldin, Eman Ahmed, Aya Osama, Sameh E. Hassanein, Hend Saed, Marwa Yassin   +9 more
doaj   +1 more source

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. [PDF]

PLoS ONE, 2014
The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44- cells.
Amit Roy, Cinzia Tesauro, Rikke Frøhlich, Marianne S Hede, Maria J Nielsen, Eigil Kjeldsen, Bjarne Bonven, Magnus Stougaard, Irina Gromova, Birgitta R Knudsen   +9 more
doaj   +1 more source

Characterization of camptothecin by analytical methods and determination of anticancer potential against prostate cancer

Future Journal of Pharmaceutical Sciences, 2021
Background Objective of present research work is to develop and validate cost-effective analytical tool for determination of camptothecin (CPT) and determine its anticancer potential against prostate cancer LNCaP cell lines.
Sunil T. Galatage, Rahul Trivedi, Durgacharan A. Bhagwat   +2 more
doaj   +1 more source

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 [PDF]

, 2007
DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs).
Arnaudeau, Avemann, Barzilai, Bendixen, Caldecott, Caldecott, Cheng, Chrencik, Christiansen, Clements, Connelly, Culmsee, Daroui, Date, Davies, Davies, Davies, de Boer, Deng, D’Arpa, El-Khamisy, Flangas, Furuta, Godthelp, Hinz, Holm, Horwitz, Hsiang, Inamdar, Interthal, Interthal, Interthal, K.W. Caldecott, Kroeger, Lanza, Lesher, Liao, Lindahl, Liu, Mol, Moreira, Morris, Nitiss, Nouspikel, O’Driscoll, Parsons, Plo, Pommier, Pommier, Pommier, Poot, Pouliot, Pouliot, Pourquier, Pourquier, Pourquier, Pourquier, Pourquier, Rideout, Ryan, Ryan, S.F. El-Khamisy, Sarkander, Sarkander, Shao, Stewart, Strumberg, Takashima, Taylor, Thompson, van Waardenburg, Vance, Vidal, Vierck, Wang, Whitehouse, Wilson, Wu, Wu, Yan, Yang, Zhou, Zhou   +82 more
core   +1 more source

Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. [PDF]

, 2016
Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits.
Butchbach, Matthew E.R., Gentillon, Cinsley, Harris, Ashlee W., Holbrook, Jennifer, Lumpkin, Casey J., McCahan, Suzanne M., Rossi, Sharyn L., Wang, Wenlan   +7 more
core   +2 more sources

Proton MR Spectroscopy of Neural Stem Cells: Does the Proton-NMR Peak at 1.28 ppm Function As a Biomarker for Cell Type or State? [PDF]

, 2011
Recently, a peak at 1.28 ppm in proton magnetic resonance spectroscopy (^1H-MRS) of neural stem cells (NSCs) was introduced as a noninterventional biomarker for neurogenesis in vivo. This would be an urgently needed requisite for translational studies in
Brandt, Moritz, Fuchs, Beate, Hermann, Andreas, Kirsch, Matthias, Loewenbrück, Kai F., Schiller, Jürgen, Schwarz, Johannes, Schwarz, Sigrid, Storch, Alexander, Werner, Annett   +9 more
core   +1 more source

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements [PDF]

, 2009
IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET.
Alley, B. C. Mack, Braet, C. A. Alabi, C. H. J. Choi, Carter, Cheng, Cheng, Davis, Davis, Dreher, Drummond, Hashizume, Heidel, Hobbs, I. J. Hildebrandt, J. Czernin, J. Hwang, Kirpotin, Loening, M. E. Davis, Matsumura, Moore, O'Connor, Reddy, Riches, Schluep, Schluep, Schluep, T. Schluep, Tabata, Tirona, Torchilin, Yuan   +33 more
core   +3 more sources

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Communications Biology, 2022
Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.
Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada   +12 more
doaj   +1 more source