Results 131 to 140 of about 11,333,085 (312)

FAP-Anchored Retinoic Acid Nanoparticles for Stromal Reprogramming and Enhanced Intratumoral Oxaliplatin Delivery in Fibrotic Colorectal Tumours

Biosensors
In colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) and the fibrotic stroma generate form a dense stromal barrier that restricts the intratumoural exposure and spatial distribution of oxaliplatin.
Haixia Wang, Can Xu, Ling Xie, Xiaohe Chu, Xinyu Liu, Peng Wang   +5 more
doaj   +1 more source

Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology

Cancer Nanotechnology, 2020
Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME ...
Kyle Bromma, Aaron Bannister, Antonia Kowalewski, Leah Cicon, Devika B. Chithrani   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The prognostic significance of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Tumor Biology, 2017
Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression.
Hyunjin Park, Yangkyu Lee, Hyejung Lee, Jin-Won Kim, Jin-Hyeok Hwang, Jaihwan Kim, Yoo-Seok Yoon, Ho-Seong Han, Haeryoung Kim   +8 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Patient derived cancer-associated fibroblasts from non-small cell lung cancer undergo phenotypic drift in culture

Nanostring nCounter targeted RNA Seq. data of fibroblast cells isolated from human non-cancerous lung tissue and non-small cell lung cancer tumour tissue as well as fibroblasts maintained for three passages in culture from both origins as shown in ...
Koppensteiner, Lilian, Jones, Phoebe, Akram, Ahsan, Dorward, David, Mathieson, Layla, O'Connor, Richard   +5 more
core   +1 more source

Prognostic impact of CD34 and SMA in cancer‐associated fibroblasts in stage I–III NSCLC

Thoracic Cancer, 2020
Background Epithelial‐to‐mesenchymal transition (EMT) is a crucial step in lung cancer pathogenesis. Among others, cancer‐associated fibroblasts (CAFs) are reported to regulate this process.
Arik Bernard Schulze, Lars Henning Schmidt, Birthe Heitkötter, Sebastian Huss, Michael Mohr, Alessandro Marra, Ludger Hillejan, Dennis Görlich, Peter J. Barth, Jan Rehkämper, Georg Evers   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cancer-associated fibroblast phenotypes predict patient outcome in non-small cell lung cancer

, 2023
Data for the manuscript "Cancer-associated fibroblast phenotypes predict patient outcome in non-small cell lung cancer " containing RAW IMC acquisition data (mcd files and .txt files), single cell objects (raw and annotated), cell and tumour-stroma ...
de Souza, Natalie, Engler, Stefanie, Bodenmiller, Bernd, Moch, Holger, Rüschoff, Jan-Hendrick, Cords, Lena, Haberecker, Martina   +6 more
core   +1 more source

Data from a proteomic analysis of colonic fibroblasts secretomes

Data in Brief, 2014
The tumor cell proliferation, migration and invasion were influenced by the interaction between the cancer cells and their microenvironment. In current study, we established two pairs of the primary fibroblast cultures from colorectal adenocarcinoma ...
Sun-Xia Chen, Xiao-En Xu, Xiao-Qing Wang, Shu-Jian Cui, Lei-Lei Xu, Ying-Hua Jiang, Yang Zhang, Hai-Bo Yan, Qian Zhang, Jie Qiao, Peng-Yuan Yang, Feng Liu   +11 more
doaj   +1 more source