Results 1 to 10 of about 11,432,431 (259)

Cancer-Associated Fibroblasts in Gastrointestinal Cancer Metastasis: Mechanisms and Emerging Therapeutic Strategies [PDF]

Drug Design, Development and Therapy
Shasha Gao,1,2 Yanru Song,1,2 Yining Qiao,1,2 Zihan Gao,1,2 Jiao Ma,1,2 Bingjie Huo,1,2 Shenghao Li,1,2 Miao Cao1,21Oncology Department of Integrated Chinese and Western Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s ...
Gao S, Song Y, Qiao Y, Gao Z, Ma J, Huo B, Li S, Cao M   +7 more
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Metabolic-suppressed cancer-associated fibroblasts limit the immune environment and survival in colorectal cancer with liver metastasis

Frontiers in Pharmacology, 2023
Background: Colorectal cancer liver metastasis is a major risk factor of poor outcomes, necessitating proactive interventions and treatments. Cancer-associated fibroblasts (CAFs) play essential roles in metastasis, with a focus on metabolic reprogramming.
Chenghao Wu, Chenghao Wu, Shaobo Yu, Shaobo Yu, Yanzhong Wang, Yanzhong Wang, Yuzhen Gao, Yuzhen Gao, Xinyou Xie, Xinyou Xie, Jun Zhang, Jun Zhang   +11 more
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Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation

Bioengineering, 2021
An understanding of the participation and modulation of fibroblasts during tumor formation and growth is still unclear. Among many speculates, one might be the technical challenge to reveal the versatile function of fibroblasts in tissue complexity, and ...
Girdhari Rijal
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Metastasis-associated fibroblasts: an emerging target for metastatic cancer

Biomarker Research, 2021
Metastasis suggests a poor prognosis for cancer patients, and treatment strategies for metastatic cancer are still very limited. Numerous studies have shown that cancer-associated fibroblasts (CAFs), a large component of the tumor microenvironment ...
Zimu Wang, Jiaxin Liu, Hairong Huang, Mingxiang Ye, Xinying Li, Ranpu Wu, Hongbing Liu, Yong Song   +7 more
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Overcoming Therapy Resistance and Relapse in TNBC: Emerging Technologies to Target Breast Cancer-Associated Fibroblasts

Biomedicines, 2021
Breast cancer is the most diagnosed cancer and is the leading cause of cancer mortality in women. Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer.
Farhana Mollah, Pegah Varamini
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Exosomes-mediated transfer of LINC00691 regulates the formation of CAFs and promotes the progression of gastric cancer

BMC Cancer, 2023
Objective Gastric cancer (GC) is one of the malignant tumors with the highest mortality worldwide. Our previous studies have revealed that LINC00691 is up-regulated in serum of GC patients as a novel potential biomarker for GC diagnosis and prognosis ...
Bin Xia, Xiuyu Gu, Tingting Xu, Meina Yan, Lan Huang, Chun Jiang, Meifen Li, Guanghua Zhai, Guoping Zhang, Jian Wu, Yu Zhou, Chunrong Sun, Wei Liang   +12 more
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Biological differences between normal and cancer-associated fibroblasts in breast cancer

Heliyon, 2023
Background: Cancer-associated fibroblasts (CAFs) constitute the primary constituents of the tumor microenvironment (TME) and exert significant influences on cancer progression.
Dengdi Hu, Wenying Zhuo, Peirong Gong, Feiyang Ji, Xun Zhang, Yongxia Chen, Misha Mao, Siwei Ju, Yuehong Pan, Jun Shen   +9 more
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Phage Ligands for Identification of Mesenchymal-Like Breast Cancer Cells and Cancer-Associated Fibroblasts

Frontiers in Oncology, 2018
Epithelial to mesenchymal transition (EMT) is believed to be crucial for primary tumors to escape their original residence and invade and metastasize. To properly define EMT, there is a need for ligands that can identify this phenomenon in tumor tissue ...
Kelvin M. Jones, Balasubramanyam Karanam, Jacqueline Jones-Triche, Maninder Sandey, Henry J. Henderson, Rajeev S. Samant, Samuel Temesgen, Clayton Yates, Deepa Bedi   +8 more
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Biomarkers for cancer-associated fibroblasts

Biomarker Research, 2020
Cancer-associated fibroblasts (CAFs) are the key component of tumor stromal. High heterogeneity of CAFs reflects in their origin, phenotype and function. Biological function which can be suggested by biomarkers of distinct CAF subgroups may be different,
Chencheng Han, Tongyan Liu, Rong Yin
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The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer

Journal of Experimental & Clinical Cancer Research, 2019
Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis.
Yuanliang Yan, Xi Chen, Xiang Wang, Zijin Zhao, Wenfeng Hu, Shuangshuang Zeng, Jie Wei, Xue Yang, Long Qian, Shuyi Zhou, Lunquan Sun, Zhicheng Gong, Zhijie Xu   +12 more
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