Results 31 to 40 of about 11,432,431 (259)

Primary cancer-associated fibroblasts exhibit high heterogeneity among breast cancer subtypes [PDF]

, 2023
Background: Cancer-associated fibroblasts (CAFs) are a diverse subset of cells, that is recently gaining in popularity and have the potential to become a new target for breast cancer therapy; however, broader research is required to understand their ...
Adamczyk, Beata; Surgical, Oncological and Endoscopic Gynaecology Department, Greater Poland Cancer Center, Poznan, Poland, Kulcenty, Katarzyna; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland, Piotrowski, Igor; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland, Fundowicz, Magdalena; Radiotherapy Ward I, Greater Poland Cancer Centre, Poznan, Poland, Suchorska, Wiktoria Maria; Department of Electroradiology, Poznan University of Medical Sciences, Poznań, Poland; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland, Musielak, Marika; Doctoral School, Poznan University of Medical Sciences, Poznan, Poland, Poland; Department of Electroradiology, Poznan University of Medical Sciences, Poznań, Poland; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland, Malicki, Julian; Department of Electroradiology, Poznan University of Medical Sciences, Poznań, Poland; Medical Physics Department, Greater Poland Cancer Centre, Poznań, Poland, Piwocka, Oliwia; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland; Department of Electroradiology, Poznan University of Medical Sciences, Poznań, Poland; Doctoral School, Poznan University of Medical Sciences, Poznan, Poland, Poland   +7 more
core   +1 more source

A peek into cancer-associated fibroblasts: origins, functions and translational impact

Disease Models & Mechanisms, 2018
In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer progresses, an accompanying host stromal response evolves within and around the nascent tumor.
Valerie S. LeBleu, Raghu Kalluri
doaj   +1 more source

The cellular triumvirate: fibroblasts entangled in the crosstalk between cancer cells and immune cells

Frontiers in Immunology
This review article will focus on subpopulations of fibroblasts that get reprogrammed by tumor cells into cancer-associated fibroblasts. Throughout this article, we will discuss the intricate interactions between fibroblasts, immune cells, and tumor ...
Adel Fergatova, Nesrine I. Affara
doaj   +1 more source

Exosomes and their roles in the chemoresistance of pancreatic cancer

Cancer Medicine, 2022
Pancreatic cancer (PC) remains one of the most lethal human malignancies worldwide. Due to the insidious onset and the rapid progression, most patients with PC are diagnosed at an advanced stage rendering them inoperable.
Yubin Pan, Honglin Tang, Qijun Li, Guangpeng Chen, Da Li   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

Cell Death and Disease, 2021
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio, Antimo Migliaccio, Anna Tesei, Gabriella Castoria   +12 more
doaj   +1 more source

Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes

Neoplasia: An International Journal for Oncology Research, 2021
The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cells ...
Dylan Dieters-Castator, Paola M. Dantonio, Matt Piaseczny, Guihua Zhang, Jiahui Liu, Miljan Kuljanin, Stephen Sherman, Michael Jewer, Katherine Quesnel, Eun Young Kang, Martin Köbel, Gabrielle M. Siegers, Andrew Leask, David Hess, Gilles Lajoie, Lynne-Marie Postovit   +15 more
doaj   +1 more source

Cancer-Associated Fibroblasts and Tumor Cells in Pancreatic Cancer Microenvironment and Metastasis: Paracrine Regulators, Reciprocation and Exosomes

, 2022
Pancreatic cancer is currently the fourth leading cause of cancer deaths in the United States, and the overall 5 year survival rate is still only around 10%.
Jörg Kleeff, Anais Zourelidis, Johanna Häußler, Yoshiaki Sunami   +3 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research Progress of Fibroblasts in Human Diseases

Biomolecules
Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell type seen in loose connective tissue. As the main components of the internal environment that cells depend on for survival, fibroblasts play an essential role in ...
Xiaodong Li, Nana Li, Yujie Wang, Qixiang Han, Boshi Sun   +4 more
doaj   +1 more source