Results 21 to 30 of about 11,432,431 (259)

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth, Olga Bermudez, Oliver Eickelberg, Olga Bermudez (410727), Ina Koch (7903), Oliver Eickelberg (153848), Eickelberg, O., Bermudez, O., Koch, I., Lindner, Michael, Elisabeth Hennen, Hennen, E., Koch, Ina, Elisabeth Hennen (410728), Bermudez, Olga, Michael Lindner, Ina Koch, Michael Lindner (383308), Lindner, M., Eickelberg, Oliver, Koch Ina, Eickelberg Oliver, Bermudez Olga, Lindner Michael, Hennen Elisabeth   +24 more
core   +2 more sources

Cancer-associated Fibroblasts Communicate with Breast Tumor Cells Through Extracellular Vesicles in Tumor Development

Technology in Cancer Research & Treatment, 2022
Breast cancer is the leading cause of cancer death among women worldwide. In solid tumors, the microenvironment plays a critical role in tumor development, and it has been described a communication between the different cell types that conform the stroma,
Rocio Castillo-Sanchez PhD, Ander Churruca-Schuind MSc, Mileidy Martinez-Ival MSc, Eduardo Perez Salazar PhD   +3 more
doaj   +1 more source

Cancer-associated fibroblasts suppress CD8+ T cell infiltration and confer resistance to immune checkpoint blockade

, 2022
Immune checkpoint blockade (ICB) promotes anti-tumor immune responses and can result in durable patient benefit. However, response rates in breast cancer patients remain modest, stimulating efforts to discover novel treatment options.
Isacke, Clare M., Isacke, CM, Jenkins, L, Harper, J, Avgustinova, Alexandra, Mills, A, Avgustinova, A, Haider, Syed, Mills, Adam, Haider, S, Iravani, Marjan, Harper, James, Jungwirth, U, Jenkins, Liam, Jungwirth, Ute, Iravani, M, Syed Haider, Adam Mills, Marjan Iravani, Liam Jenkins, Alexandra Avgustinova, James Harper, Clare M. Isacke, Ute Jungwirth   +23 more
core   +1 more source

Isolation of cancer‐associated fibroblasts and its promotion to the progression of intrahepatic cholangiocarcinoma

Cancer Medicine, 2018
Intrahepatic cholangiocarcinoma is a highly fatal tumor characterized by an abundant stromal environment. Cancer‐associated fibroblasts play key roles in tumor growth and invasiveness and have been regarded as a potential therapeutic target.
Meng Sha, Seogsong Jeong, Bi‐jun Qiu, Ying Tong, Lei Xia, Ning Xu, Jian‐jun Zhang, Qiang Xia   +7 more
doaj   +1 more source

Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression

Frontiers in Cell and Developmental Biology, 2018
This review summarizes the roles of CAFs in forming a “cancerized” fibrotic stroma favorable to tumor initiation and dissemination, in particular highlighting the functions of the extracellular matrix component hyaluronan (HA) in these processes.
James B. McCarthy, Dorraya El-Ashry, Eva A. Turley   +2 more
doaj   +1 more source

Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells

BMC Cancer, 2021
Background Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior.
Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato   +8 more
doaj   +1 more source

Cancer-associated fibroblasts secret extracellular vesicles to support cell proliferation and epithelial-mesenchymal transition in laryngeal squamous cell carcinoma

Molecular and Cellular Probes, 2023
As the critical components of tumor microenvironment, cancer-associated fibroblasts (CAFs) support the development of various type of cancers, including laryngeal squamous cell carcinoma (LSCC), but the detailed molecular mechanisms by which cancer ...
Tingting Li, Linli Tian, Jing Cao, Ming Liu   +3 more
doaj   +1 more source

Evaluation of the significance of tumor stromal patterns and peri-tumoral inflammation in head and neck squamous cell carcinoma with special reference to the Yamamoto–Kohama classification

Indian Journal of Pathology and Microbiology
Introduction: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with 878,348 new cases. Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor stroma and are important promoters of tumor ...
Geet Bhuyan, Prabir Hazarika, Anju M. Rabha   +2 more
doaj   +1 more source

Cellular Heterogeneity of Pancreatic Stellate Cells, Mesenchymal Stem Cells, and Cancer-Associated Fibroblasts in Pancreatic Cancer

, 2020
Pancreatic cancer is projected to become the second deadliest cancer by 2030 in the United States, and the overall five-year survival rate stands still at around 9%.
Jörg Kleeff, Johanna Häußler, Yoshiaki Sunami   +2 more
core   +1 more source

Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells

, 2021
Fibroblasts in the tumor microenvironment, known as cancer-associated fibroblasts (CAFs), promote the migration, invasion, and metastasis of cancer cells when they are activated through diverse processes, including post-transcriptional regulation by ...
안영호, 이지희
core   +1 more source