Results 11 to 20 of about 11,432,431 (259)

Cytokine Interaction With Cancer-Associated Fibroblasts in Esophageal Cancer [PDF]

Cancer Control, 2022
Esophageal cancer (EC) is a highly aggressive cancer with poor outcomes under current treatment regimens. More recent findings suggest stroma elements, specifically cancer-associated fibroblasts (CAFs), play a role in disease occurrence and progression ...
Md Sazzad Hassan MD, PhD, Nicholas Cwidak BS, Niranjan Awasthi PhD, Urs von Holzen MD, MBA, FACS   +3 more
doaj   +2 more sources

Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer [PDF]

Frontiers in Oncology, 2015
Colorectal cancer progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells and diverse immune cells ...
Joke eTommelein, Laurine eVerset, Tom eBoterberg, Pieter eDemetter, Marc eBracke, Olivier eDe Wever   +5 more
doaj   +2 more sources

Targeting and Reprograming Cancer-Associated Fibroblasts and the Tumor Microenvironment in Pancreatic Cancer [PDF]

, 2021
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States both in female and male, and is projected to become the second deadliest cancer by 2030. The overall five-year survival rate remains at around 10%.
Viktoria Böker, Jörg Kleeff, Yoshiaki Sunami   +2 more
core   +2 more sources

Novel signatures of cancer-associated fibroblasts [PDF]

, 2013
Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression.
Csermely, Péter, Klein, George, Dúl, Zoltán, Székely, László, Korcsmáros, Tamás, Bozóky, Benedek, Savchenko, Andrii, Pontén, Fredrik,   +7 more
core   +2 more sources

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression [PDF]

, 2015
Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma ...
Gersten, Adam, Prystowsky, Michael, Wang, Yanghua, Moleirinho, Susana, Gunn-Moore, Frank, Reynolds, Paul Andrew, Michael B. Prystowsky MD, PhD, Adam Gersten MD, Yanghua Wang MD, PhD, Paul A. Reynolds PhD, Frank J. Gunn-Moore PhD, Susana Moleirinho PhD, Reynolds, Paul Andrew; id_orcid, Gunn-Moore, Frank; id_orcid   +13 more
core   +1 more source

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer [PDF]

, 2013
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s ...
Chang, AndyC -M,, Mezheyeuski, Artur, Gallardo, Alberto, Jirström, Karin, Edqvist, Per-Henrik,, Jirstrom, Karin,, Sandström, Per,, Kiflemariam, Sara,, Chang, Andy C-M, Mangues, Ramon,, Pena, Cristina, Birgisson, Helgi,, Veerla, Srinivas, Ostman, Arne,, Gallardo, Alberto,, Céspedes, María Virtudes, Reddel, Roger R.,, Kiflemariam, Sara, Veerla, Srinivas,, Olsson, Eleonor,, Augsten, Martin,, Chang, Andy C.-M., Edqvist, Per-Henrik, Reddel, Roger R, Reddel, Roger R., Mezheyeuski, Artur,, Virtudes Cespedes, Maria, Lindh, Maja Bradic, Augsten, Martin, Bradic Lindh, Maja,, Virtudes Cespedes, Maria,, Hägglöf, Christina,, Bojmar, Linda,, Pena, Cristina,, Peña Maroto, Cristina, Sjöblom, Tobias,, Lund University., Birgisson, Helgi, Olsson, Eleonor, Bojmar, Linda, Chang, Andy C. -M., Mangues, Ramón, Edqvist, P-H, Jirstrom, K, Birgisson, H, Bojmar, L, Sandström, Per, Lindh, MB, Sjöblom, Tobias, Pena, C, Hagglof, C, Mezheyeuski, A,, Kiflemariam, S, Östman, Arne, Hägglöf, Christina, Cespédes, Virtudes M., Virtudes, Cespedes M   +56 more
core   +1 more source

Understanding Breast-Cancer-Associated Fibroblasts and Their Epigenetic Activation to Unveil Novel Targets for Breast Cancer Therapy

, 2023
The review article ‘Cancer-Associated Fibroblasts: Epigenetic Regulation and Therapeutic Intervention in Breast Cancer’ by Lee et al [...
Aamir Ahmad
core   +1 more source

Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer. [PDF]

, 2010
Cancer-associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis.
Pena, C, Carlsson, Peter,, Peña, Cristina, Jirström, Karin, Paulsson, J,, Edlund, Karolina, Ostman, Arne, Carlsson, Peter, Saito, R-A, Miyazono, Kohei, Micke, P, Botling, Johan,, Botling, Johan, Jonsson, P, Johansson, Leif, Carlsson, P, Micke, Patrick, Edlund, Karolina,, Johansson, L, Saito, Roy-Akira, Augsten, Martin, Paulsson, Janna, Augsten, M,, Micke, Patrick,, Edlund, K, Botling, J, Jönsson, Per, Johansson, Leif,, Jirström, Karin,, Lund University.   +29 more
core   +1 more source

Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth

, 2020
[[abstract]]Background Our previous study demonstrated that lysine demethylase 2A (KDM2A) enhances stemness in breast cancer cells. This demethylase is also highly expressed in cancer-associated fibroblasts (CAFs).
Chen, JY;Li, CF;Lai, YS;Hung, WC
core   +1 more source

Tumour-stroma interaction : cancer-associated fibroblasts as novel targets in anti-cancer therapy?

, 2004
Stroma cells, together with extracellular matrix components, provide the microenvironment that is pivotal for cancer cell growth, invasion and metastatic progression. Characteristic stroma alterations accompany or even precede the malignant conversion of
Micke, Patrick,, Östman, Arne,
core   +4 more sources