Results 161 to 170 of about 11,333,085 (312)

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. [PDF]

UNLABELLED: Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to improving patient outcomes. We identified four histology-independent archetype TMEs in treatment-naïve early-stage lung cancer using imaging mass ...
Green, M, Salgado, R, Karasaki, T, Jamal-Hanjani, M, Lee, C, Shimato, M, Hobson, PS, Quezada, SA, TRACERx consortium,, Sahai, E, Swanton, C, Enfield, KSS, Angelova, M, Sivakumar, M, Glass, B, Hiley, CT, Pich, O, Reading, JL, Dijkstra, KK, Puttick, C, Moore, DA, Levi, D, van Maldegem, F, Grigoriadis, K, Hackshaw, A, Magness, A, Walk, E, Downward, J, Nye, EL, Akarca, AU, McGranahan, N, Colliver, E, Veeriah, S, Pulaski, H, Marafioti, T   +34 more
core   +1 more source

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

, 2020
International audienceAbstract Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown.
Mermet-Meillon, Fanny, Parrini, Maria, Carla, Bonnet, Isabelle, Barbazan, Jorge, Pelon, Floriane, Bourachot, Brigitte, Bonneau, Claire, Descroix, Stéphanie, Costa, Ana, Vincent-Salomon, Anne, Attieh, Youmna, Kieffer, Yann, Magagna, Ilaria, Givel, Anne-Marie, Fuhrmann, Laetitia, Mechta-Grigoriou, Fatima, Vignjevic, Danijela, Silberzan, Pascal   +17 more
core   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Cancer-associated fibroblasts: challenges and opportunities

Oncotarget, 2023
Tavana, Hossein, Luker, Gary D.
openaire   +2 more sources

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

Fibroblast-associated protection against hypoxia and carboplatin-induced cytotoxicity during coculture with osteosarcoma

Molecular Medicine
Background Osteosarcoma progression and treatment resistance are strongly influenced by the tumour microenvironment. One of the key players in tumour microenvironments is cancer-associated fibroblast. Much of the conventional cancer-associated fibroblast-
Hans Zoellner, Duan Ni, Jhati Kakani, Jingyi Zhou, Brigitta Sabrina Auwyang, Yogambha Ramaswamy, Belal Chami   +6 more
doaj   +1 more source