Results 11 to 20 of about 3,014,693 (296)

Cancer cachexia

Zdravniški Vestnik, 2013
The present article presents the Slovenian multidisciplinary agreement statement on the definition, staging, clinical classification and multimodal approach to the treatment of cachexia in cancer patients.
Nada Rotovnik Kozjek, Živa Mrevlje, Barbara Koroušič Seljak, Katja Kogovšek, Branko Zakotnik, Iztok Takač, Matjaž Horvat, Tadej Dovšak, Vojko Didanović, Andrej Kansky, Jožica Červek, Vanja Velenik, Franc Anderluh, Milena Kerin, Matjaž Sever, Primož Strojan, Borut Štabuc, Mojca Unk, Jernej Benedik, Erik Brecelj, Tadeja Pintar, Lidija Kompan, Marko Novak, Laura Petrica, Denis Mlakar Mastnak, Brigita Avramović Brumen, Eva Peklaj, Rajmonda Jankovič, Urška Jelenko, Edita Rotner, Sanja Đukić, Petra Tavčar   +31 more
doaj   +3 more sources

Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway [PDF]

Frontiers in Oncology
BackgroundCancer cachexia is a multisystem syndrome characterized by progressive skeletal muscle atrophy, anorexia, and weight loss, imposing a substantial global health burden.
Yong-Fei Wang, Yong-Fei Wang, Yong-Fei Wang, Yuan-Yuan Xin, Si-Yuan Wang, Zi-Yi An, Dong-Yang Qi, Wen- Li, Wei-Lin Jin, Wen-Zhen Yuan, Wen-Zhen Yuan   +10 more
doaj   +2 more sources

Screening Assessment and Therapy Intervention of Cancer Cachexia in Adult Patients——Based on the Interpretation of Cancer Cachexia in Adult Patients: ESMO Clinical Practice Guidelines [PDF]

Zhongguo quanke yixue, 2023
Cancer cachexia is a cancer-related, multi-factorial, irreversible clinical syndrome characterized by progressive nutritional consumption, which greatly reduces the survival expectation and quality of life of cancer patient.
WANG Rui, WANG Xiaomei, PENG Guoqing, YU Huan, WANG Sihan, XIA Jin
doaj   +1 more source

Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer‐induced cachexia

JCSM Rapid Communications, 2022
Background Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared with cancer patients without weight loss.
Jeffery M. Chakedis, Mary E. Dillhoff, Carl R. Schmidt, Priyani V. Rajasekera, David C. Evans, Terence M. Williams, Denis C. Guttridge, Erin E. Talbert   +7 more
doaj   +1 more source

Targeting cancer cachexia: Molecular mechanisms and clinical study

MedComm, 2022
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer cachexia environment. During the occurrence and progression of cancer cachexia,
Yong‐Fei Wang, Zi‐Yi An, Dong‐Hai Lin, Wei‐Lin Jin   +3 more
doaj   +1 more source

Cancer cachexia

Journal of Parenteral and Enteral Nutrition, 1988
Cancer cachexia describes a syndrome of progressive weight loss, anorexia, and persistent erosion of host body cell mass in response to a malignant growth. Although often associated with preterminal patients bearing disseminated disease, cachexia may be present in the early stages of tumor growth before any signs or symptoms of malignancy. A decline in
K A, Kern, J A, Norton
  +8 more sources

Cancer cachexia [PDF]

QJM: An International Journal of Medicine, 2005
Cancer cachexia is a severe debilitating disorder for which there are currently few therapeutic options. It is driven by the release of pro-inflammatory cytokines and cachectic factors by both host and tumour. Over the past few years, basic science advances have begun to reveal the breadth and complexity of the immunological mechanisms involved, and in
J N, Gordon, S R, Green, P M, Goggin
openaire   +2 more sources

Physical function endpoints in cancer cachexia clinical trials : systematic review 1 of the cachexia endpoints series [PDF]

, 2023
In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures.
Dolan, R., McDonald, J., Hjermstad, M, Jamal-Hanjani, M, Jakobsen, G., Arends, J, Arends, J., Sayers, J, Sousa, MS, Simpson, MR, Anker, S. D., Brown, L., Jamal-Hanjani, M., Balstad, TR, McDonald, J, Cancer Cachexia Endpoints Working Group,, Fraser, E, Anker, SD, Sayers, J., Laird, BJA, Vagnildhaug, O. M., Hjermstad, M., Solheim, TS, Griel, C., Kaasa, S., McMillan, D., Griel, C, Jakobsen, G, Dajani, O, Bye, A., Cancer Cachexia Endpoints Working Group, Solheim, T. S., Kaasa, S, Brown, L, Maddocks, M, Reid, KF, McMillan, D, Bye, A, Fraser, E., Maddocks, M., Grzyb, A, Balstad, T. R., Ottestad, I. O., Skipworth, RJE, Ottestad, IO, Philips, I., Vagnildhaug, OM, Reid, K. F., Dolan, R, Laird, B. J., Baracos, V, Fallon, M. T., Simpson, M. R., Philips, I, Souza e Sousa, Mariana S. de (R18695), Baracos, V., Grzyb, A., Dajani, O., Skipworth, R. J., Fallon, MT   +59 more
core   +1 more source

The Adipokines in Cancer Cachexia [PDF]

International Journal of Molecular Sciences, 2020
Cachexia is a devastating pathology induced by several kinds of diseases, including cancer. The hallmark of cancer cachexia is an extended weight loss mainly due to skeletal muscle wasting and fat storage depletion from adipose tissue. The latter exerts key functions for the health of the whole organism, also through the secretion of several adipokines.
Mannelli M., Gamberi T., Magherini F., Fiaschi T.   +3 more
openaire   +2 more sources

Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study

Journal of Cachexia, Sarcopenia and Muscle, 2021
Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1 year mortality of patients with cancer ...
Mengmeng Song, Qi Zhang, Meng Tang, Xi Zhang, Guotian Ruan, Xiaowei Zhang, Kangping Zhang, Yizhong Ge, Ming Yang, Qinqin Li, Xiangrui Li, Xiaoyue Liu, Wei Li, Minghua Cong, Kunhua Wang, Chunhua Song, Hanping Shi   +16 more
doaj   +1 more source