Results 61 to 70 of about 3,021,316 (188)

Free Radical Scavenging and In vitro Cytotoxic Activity of Bugnay (Antidesma bunius) Leaves Extract against A549 Human Lung Adenocarcinoma and HCT-116 Human Colorectal Cancer Cell Lines [PDF]

, 2020
Cancer is one of the significant causes of mortality worldwide. Studies on antineoplastic drugs focused on natural products have revealed several mechanisms to inhibit cancer cells.
Soliba, Lycon Marie L., Tagalog, Alta Christine Marie M., Ildefonso, Jeric John C., Geronimo, Arnold Joseph O., Domantay, John Anthony A., Bancual, Mari Erika Joi F., Santos, Crisel B., Ko, Karl Anthony L., Buñag, Leo Emmanuel R., Chan, Joanna Kaitlin G., Gresh, Cassandra B., Soriano, Angelica Mae B., Ang, Vincent S., Apigo, Mariebon A., Acosta, Nikolai E., Buenconsejo, Dana Grace S.   +15 more
core   +3 more sources

Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib

Journal of Experimental & Clinical Cancer Research, 2019
Background Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and high incidence of acquired resistance resulted from elevated levels of ...
Ning Zheng, Weiqun Liu, Bifei Li, Huifang Nie, Jian Liu, Yunlong Cheng, Jichuang Wang, Haiyan Dong, Lee Jia   +8 more
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Anti-metastatic Activity of Curcumin Analog Pentagamaboronon-0-Sorbitol Against HER2-overexpressed MCF-7 Breast Cancer Cells [PDF]

, 2018
Breast cancer with Human Epidermal Growth Factor Receptor (HER)2 overexpression increases tumor progession and lead to metastasis, which is primarily cause of mortality in breast cancer.
Qodria, Lailatul, Hairunisa, Indah, Hermawan, Adam, Utomo, Rohmad Yudi, Meiyanto, Edy   +4 more
core   +1 more source

Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid

Asian Journal of Pharmaceutical Sciences, 2020
Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao, Yifan Fang, Ruirui Zhao, Fangmin Chen, Mingyue Yang, Jiali Jiang, Zixuan Chen, Xiaotian Yuan, Lee Jia   +8 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

The Role of Curcumin on Apoptosis through The RASSF1A and Bax Pathways in Breast Cancer [PDF]

, 2020
Curcumin has been reported with an in vitro the cytotoxic effect on several human cancer cells. However, reports on the mode of action and detail mechanism of curcumin in breast cancer disease are limited.
Harliansyah, Harliansyah, Rustamadji, Primariadewi, Suyatna, Fransiscus D., Prihartono, Joedo, Hernowo, Bethy Suryawati, Haryono, Samuel Johny, Rahmah, Nunung Ainur, Kanoko, Mpu   +7 more
core   +1 more source

A Sulfur-Bridging Sulfonate-Modified Zinc(II) Phthalocyanine Nanoliposome Possessing Hybrid Type I and Type II Photoreactions with Efficient Photodynamic Anticancer Effects

Molecules, 2023
Phthalocyanines are potentially promising photosensitizers (PSs) for photodynamic therapy (PDT), but the inherent defects such as aggregation-caused quenching effects and non-specific toxicity severely hinder their further application in PDT.
Zixuan Chen, Yuan-Yuan Zhao, Li Li, Ziqing Li, Shuwen Fu, Yihui Xu, Bi-Yuan Zheng, Meirong Ke, Xingshu Li, Jian-Dong Huang   +9 more
doaj   +1 more source

Effects of Green Tea Supplementation on Chemoprevention at Different Stages of Carcinogenesis: A Systematic Review

Phytotherapy Research, EarlyView.
ABSTRACT Green tea catechins have chemopreventive potential; however, the clinical evidence remains inconsistent. This review evaluated the effects of supplementation with green tea derivatives on chemoprevention at different stages of carcinogenesis. PubMed, Embase, Web of Science, Scopus, the Cochrane Library, CINAHL, and Google Scholar were searched
Thaís Moreira Machado, Mariene Garcia Gomes, Érika Yuri Hirose Murahara, Ana Lúcia Chalhoub Chediac Rodrigues, Ariane Nadolskis Severine, Thais Giovaninni Roberto, Sinara Laurini Rossato   +6 more
wiley   +1 more source

Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells [PDF]

, 2020
Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells
Nugraha, Ari Satia, Kusumawardani, Banun, Puspitasari, Endah, Rosidah, Malihatul, Azis, Deri Abdul, Febi, Qonita Nafilah   +5 more
core   +1 more source