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Pediatric Research, 2006 Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers.
Wei, Guo, Joseph L, Lasky, Hong, Wu
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American Society for Clinical Laboratory Science, 2012 The cancer stem cell (CSC) hypothesis has had a major effect on the fields of cancer cell biology and clinical oncology. CSCs were originally described in hematologic malignancies, and subsequently in a variety of solid tumors. Their unique biological characteristics, including self-renewal capability, stem cell signaling pathways, relative quiescence ...
Katarzyna, Wieczorek +1 more
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Collagen Type I Induces a Balance in the Expression of Anti- and Pro-Apoptotic Genes in Hepatocellular Carcinoma Cells [PDF]
Middle East Journal of Cancer, 2022 Background: The importance of extracellular matrix (ECM) components in the progression of hepatocellular carcinoma (HCC) has been shown in many studies. Although restoring or activating apoptosis in tumors is an active area of cancer research, little is ...
Yaprak Donmez Cakil +4 more
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Stem cells, cancer, and cancer stem cells [PDF]
Nature, 2001 Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Reya, T. +3 more
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BMC Cancer, 2021 Background Infiltrating immune and stromal cells are important components of the endometrial cancer (EC) microenvironment, which has a significant effect on the biological behavior of EC, suggesting that unique immune-related genes may be associated with
Yichen Wang +5 more
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Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. [PDF]
, 2016 The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade.
Banno, Asoka +15 more
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Sp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma
Scientific Reports, 2022 Tumor immune microenvironment exerts a profound effect on the population of infiltrating immune cells. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in a variety of cells, particularly during inflammation and tissue ...
Lu Liu +16 more
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Journal of Oncology, 2011 The concept of cancer stem cells has generated significant interests among cancer researchers. This has led to proliferative number of publications on the subject in the recent years and eventually controversies because of conflicting data in the literature.
Lu, Bo +3 more
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Signal Transduction and Targeted Therapy, 2022 Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown.
SiSi Li +30 more
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eLife, 2021 Targeting DNA repair pathway offers an important therapeutic strategy for Homo sapiens (human) cancers. However, the failure of DNA repair inhibitors to markedly benefit patients necessitates the development of new strategies.
Qiaoling Liu +8 more
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