Results 21 to 30 of about 1,025,329 (302)
PTEN, Stem Cells, and Cancer Stem Cells [PDF]
Journal of Biological Chemistry, 2009 Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Reginald, Hill, Hong, Wu
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Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]
, 2019 Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik +8 more
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Prostate Stem Cells and Cancer Stem Cells [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Jia J, Li, Michael M, Shen
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Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]
, 2016 The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela +10 more
core +9 more sources
RBM4 regulates cellular senescence via miR1244/SERPINE1 axis
Cell Death and Disease, 2023 Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer development.
Luning Wang +13 more
doaj +1 more source
Breast cancer stem cells [PDF]
Frontiers in Physiology, 2013 Cancer metastasis, resistance to therapies and disease recurrence are significant hurdles to successful treatment of breast cancer. Identifying mechanisms by which cancer spreads, survives treatment regimes and regenerates more aggressive tumors are critical to improving patient survival.
Owens, Thomas W., Naylor, Matthew J.
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Mutasi Gen p53: Faktor Prediktif Kanker Payudara?
Indonesian Journal of Cancer, 2008 Farmakogenetik dalam terapi kanker adalah pemberian terapi kepada pasien berdasarkan status atau profil genetik dari sel kanker. Dengan demikian, pemberian kemoterapi diharapkan bisa lebih efektif dan meningkatkan kualitas hidup pasien dengan menghindari
Putri Y. Suyanto +2 more
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The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
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Efek Mutasi K-RAS pada Kanker Kolorektal terhadap Terapi Antibodi Monoklonal anti EGFR
Indonesian Journal of Cancer, 2008 Kanker kolorektal merupakan salah satu jenis kanker yang banyak diderita oleh masyarakat dan dapat disembuhkan jika terdeteksi dini. Salah satu penyebab kanker adalah terjadinya mutasi pada gen-gen tertentu.
Farid Sastra Nagara +2 more
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Complexity in cancer stem cells and tumor evolution: towards precision medicine [PDF]
, 2017 In this review, we discuss recent advances on the plasticity of cancer stem cells and highlight their relevance to understand the metastatic process and to guide therapeutic interventions.
La Porta, Caterina A. M. +1 more
core +2 more sources