Results 71 to 80 of about 1,018,827 (204)

Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species

Cells
Dauricine has been shown to possess intriguing anti-cancerous activities against various malignancies. The current study examined the inhibitory effects of dauricine against lung adenocarcinoma with cell lines and animal models.
Waleed Yousuf, Nimra Zafar Siddiqui, Perbhat Ali, Shaoxuan Cheng, Immad Ansari, Jialiang Song, Minghe Dai, Zhiyuan Qiu, Yue Zhu, Yaowen Zhang, Shuyan Liu, Yingqiu Zhang, Zhenhua Liu, Han Liu   +13 more
doaj   +1 more source

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

BMC Cancer, 2019
Background Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2),
Noha-Ehssan Mohamed, Trevor Hay, Karen R. Reed, Matthew J. Smalley, Alan R. Clarke   +4 more
doaj   +1 more source

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

Urothelial Cancer Stem Cells [PDF]

The Scientific World JOURNAL, 2010
There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy.
Irena Dimov, Milan Visnjic, Vladisav Stefanovic   +2 more
openaire   +3 more sources

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

eLife, 2016
Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and ...
Shi Yun Yeo, Yoko Itahana, Alvin Kunyao Guo, Rachel Han, Kozue Iwamoto, Hung Thanh Nguyen, Yi Bao, Kai Kleiber, Ya Jun Wu, Boon Huat Bay, Mathijs Voorhoeve, Koji Itahana   +11 more
doaj   +1 more source

RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation

Breast Cancer Research, 2022
Epithelial-to-mesenchymal transition (EMT) is a critical underpinning process for cancer progression, recurrence and resistance to drug treatment. Identification of new regulators of EMT could lead to the development of effective therapies to improve the
Subbulakshmi Karthikeyan, Patrick J. Casey, Mei Wang   +2 more
doaj   +1 more source

Rac1 drives intestinal stem cell proliferation and regeneration [PDF]

, 2013
Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti, Amcheslavsky, Ashton, Biteau, Brand, Buchon, Buchon, Choi, Cordero, el Marjou, Ellenbroek, Hochmuth, Ito, Jiang, Julia Cordero, Kevin Myant, Kitagishi, Marcos Vidal, Micchelli, Miyamoto, Myant, Ohlstein, Owen Sansom, Owusu-Ansah, Radtke, Sara Haque, Tothova, Tsatmali, Walmsley   +28 more
core   +1 more source

Cancer, stem cell misplacement and cancer stem cells

Journal of Cellular and Molecular Medicine, 2013
AbstractThe cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi‐stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis ...
openaire   +2 more sources

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Cell Death and Disease, 2023
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. [PDF]

, 2008
The cancer stem cell hypothesis proposes that cancers arise in stem/progenitor cells through disregulation of self-renewal pathways generating tumors, which are driven by a component of 'tumor-initiating cells' retaining stem cell properties.
IOVINO, Flora, KORKAYA H, PAULSON A, WICHA MS   +3 more
core   +1 more source