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Systems Biology Understanding of the Effects of Lithium on Cancer [PDF]
Frontiers in Oncology, 2018 Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action.
Weihao Ge, E. Jakobsson
semanticscholar +6 more sources
Systems biology in the frontier of cancer research: a report of the Second International Workshop of Cancer Systems Biology [PDF]
Chinese Journal of Cancer, 2012 The report summarizes the Second International Workshop of Cancer Systems Biology held on July 5-6, 2012 in Changchun, China. The goal of the workshop was to bring together cancer researchers with different backgrounds to share their views about cancer ...
Cui, Juan, Liang, Yan-Chun, Xu, Ying
core +5 more sources
Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +4 more sources
Cancer Systems Biology: a peek into the future of patient care? [PDF]
Nat Rev Clin Oncol, 2014 Werner HM, Mills GB, Ram PT.
europepmc +2 more sources
Omics/systems biology and cancer cachexia.
Seminars in Cell & Developmental Biology, 2016 Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology.
I. Gallagher +4 more
semanticscholar +5 more sources
Can Systems Biology Advance Clinical Precision Oncology? [PDF]
, 2021 Precision oncology is perceived as a way forward to treat individual cancer patients. However, knowing particular cancer mutations is not enough for optimal therapeutic treatment, because cancer genotype-phenotype relationships are nonlinear and dynamic.
Kholodenko, Boris N, Rocca, Andrea
core +1 more source
Recent Developments in Cancer Systems Biology [PDF]
, 2022 This ebook includes original research articles and reviews to update readers on the state of the art systems approach to not only discover novel diagnostic and prognostic biomarkers for several cancer types, but also evaluate methodologies to map out ...
core +1 more source
A systems biology view of cancer [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009 In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Vladimir Shulaev +10 more
openaire +3 more sources
Genome Biology, 2022 Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development ...
Lisa Dressler +15 more
doaj +1 more source