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Cancer vaccines in the clinic [PDF]
Bioengineering & Translational Medicine, 2023 AbstractVaccines are an important tool in the rapidly evolving repertoire of immunotherapies in oncology. Although cancer vaccines have been investigated for over 30 years, very few have achieved meaningful clinical success. However, recent advances in areas such antigen identification, formulation development and manufacturing, combination therapy ...
Morgan E. Janes +4 more
openaire +4 more sources
Advances in mRNA-Based Cancer Vaccines [PDF]
Vaccines, 2023 Cancer is a leading cause of death worldwide, accounting for millions of deaths every year. Immunotherapy is a groundbreaking approach for treating cancer through harnessing the power of the immune system to target and eliminate cancer cells.
Ling Ni
doaj +2 more sources
Recent Findings on Therapeutic Cancer Vaccines: An Updated Review [PDF]
BiomoleculesCancer remains one of the global leading causes of death and various vaccines have been developed over the years against it, including cell-based, nucleic acid-based, and viral-based cancer vaccines.
Sara Sheikhlary +3 more
doaj +2 more sources
Empowering standardization of cancer vaccines through ontology: enhanced modeling and data analysis [PDF]
Journal of Biomedical SemanticsBackground The exploration of cancer vaccines has yielded a multitude of studies, resulting in a diverse collection of information. The heterogeneity of cancer vaccine data significantly impedes effective integration and analysis.
Jie Zheng +12 more
doaj +2 more sources
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Communications Biology, 2022 A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.
Etsuro Nanishi +20 more
doaj +1 more source
npj Vaccines, 2023 Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies ...
Etsuro Nanishi +30 more
doaj +1 more source
Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]
, 2009 Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando +3 more
core +2 more sources
Vaccines for Lung Cancer [PDF]
Journal of Thoracic Oncology, 2006 Immunotherapy is based on the knowledge that the immune system can distinguish cancerous cells from normal cells. Conceptually, this is an attractive adjuvant approach because it is highly specific and can deal with disseminated disease with minimal impact on normal tissues.
Edward A. Hirschowitz +2 more
openaire +3 more sources
Uptake of three doses of HPV vaccine by primary school girls in Eldoret, Kenya : a prospective cohort study in a malaria endemic setting [PDF]
, 2018 Background: All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year.
Kirop, Elijah +8 more
core +3 more sources
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies
Cell Reports, 2021 Summary: An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by ...
Emilie Seydoux +13 more
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