Results 21 to 30 of about 5,770,101 (353)
Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]
, 2009 Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando +3 more
core +2 more sources
Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities
Frontiers in Immunology, 2023 Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-19, researchers have been striving to develop mRNA vaccines for clinical use, including those exploited for anti-tumor therapy.
Bolin Wang +4 more
semanticscholar +1 more source
Vaccines, 2023 At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in macaques.
Massimiliano Bissa +23 more
doaj +1 more source
Trends in Pharmacological Sciences, 1993 1993 represents the 100th anniversary of William Coley's first report of tumor regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy.
openaire +4 more sources
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Communications Biology, 2022 A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.
Etsuro Nanishi +20 more
doaj +1 more source
EBioMedicine, 2021 Background: Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected individuals, which has been attributed to cross-reactive CD4 memory T cells from
Isaac Quiros-Fernandez +3 more
doaj +1 more source
Aging, cancer, and cancer vaccines [PDF]
Immunity & Ageing, 2012 AbstractWorld population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between 8 and 10.5 billion people within 40 years.
MAZZOLA, PAOLO +6 more
openaire +3 more sources
Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy
Frontiers in Immunology, 2023 Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various immune cell types and perform multiple purposes and duties involved in the induction of innate and adaptive immunity.
Samik Chakraborty +6 more
semanticscholar +1 more source
npj Vaccines, 2023 Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies ...
Etsuro Nanishi +30 more
doaj +1 more source