Results 31 to 40 of about 3,308,693 (307)
Engineering New Approaches to Cancer Vaccines [PDF]
, 2015 available in PMC 2016 August 01Recently, a number of promising approaches have been developed using synthetic chemistry, materials science, and bioengineering-based strategies to address challenges in the design of more effective cancer vaccines.
Irvine, D. J. +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Vaccines Against Non-Infectious, Non-Cancer Novel Targets
, 2015 This chapter discusses vaccines against non-infectious, non-cancer novel targets. It is part of a collection which takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines
Nimmo, Natalie +7 more
core +4 more sources
p30 protein: a critical regulator of HTLV-1 viral latency and host immunity
Retrovirology, 2019 The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the severity of the health conditions associated with the virus impress the great need for basic and translational research to ...
Ramona Moles +8 more
doaj +1 more source
Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death
Journal of Experimental & Clinical Cancer Research, 2022 Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the activation of host antitumor immune response in tumor immune microenvironment ...
Xuhui Bao, Liyi Xie
doaj +1 more source
BMJ, 2015 Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a ...
openaire +3 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cancer Vaccines for Genitourinary Tumors: Recent Progresses and Future Possibilities
, 2021 Background: In the last years, many new treatment options have widened the therapeutic scenario of genitourinary malignancies. Immunotherapy has shown efficacy, especially in the urothelial and renal cell carcinomas, with no particular relevance in ...
Evaristo Maiello +6 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Detecting horizontal gene transfer with metagenomics co-barcoding sequencing
Microbiology SpectrumHorizontal gene transfer (HGT) is the process through which genetic information is transferred between different genomes and that played a crucial role in bacterial evolution.
Kai Han +10 more
doaj +1 more source