Human papillomavirus vaccination coverage in Luxembourg : implications of lowering and restricting target age groups [PDF]
, 2018 Background: In Luxembourg, a national Human Papillomavirus (HPV) vaccination programme was introduced in 2008, targeting 12-17 year old girls offering a choice of bivalent or quadrivalent vaccine free of charge.
Arbyn, Marc +3 more
core +2 more sources
Cancer Vaccines: Promising Therapeutics or an Unattainable Dream
Vaccines, 2021 The advent of cancer immunotherapy has revolutionized the field of cancer treatment and offers cancer patients new hope. Although this therapy has proved highly successful for some patients, its efficacy is not all encompassing and several cancer types ...
H. Donninger +3 more
semanticscholar +1 more source
Scientific Reports, 2018 The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, biofilm-like structures and cellular conduits have been ...
Maria Omsland +8 more
doaj +1 more source
Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. [PDF]
, 2018 Nanoparticles have attracted considerable interest as cancer vaccine delivery vehicles for inducing sufficient CD8+ T cell-mediated immune responses to overcome the low immunogenicity of the tumor microenvironment.
Kim, Tae Il +5 more
core +2 more sources
p30 protein: a critical regulator of HTLV-1 viral latency and host immunity
Retrovirology, 2019 The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the severity of the health conditions associated with the virus impress the great need for basic and translational research to ...
Ramona Moles +8 more
doaj +1 more source
Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death
Journal of Experimental & Clinical Cancer Research, 2022 Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the activation of host antitumor immune response in tumor immune microenvironment ...
Xuhui Bao, Liyi Xie
doaj +1 more source
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer
NatureA fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ...
Zachary M. Sethna +46 more
semanticscholar +1 more source
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies
Theranostics, 2022 Rationale: Messenger RNA (mRNA) vaccine outperforms other kinds of cancer immunotherapy due to its high response rates, easy preparation, and wide applicability, which is considered as one of the most promising forms of next-generation cancer therapies ...
Hongjian Li +8 more
semanticscholar +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Detecting horizontal gene transfer with metagenomics co-barcoding sequencing
Microbiology SpectrumHorizontal gene transfer (HGT) is the process through which genetic information is transferred between different genomes and that played a crucial role in bacterial evolution.
Kai Han +10 more
doaj +1 more source