Results 21 to 30 of about 17,554 (214)

Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance

Pharmaceutics, 2021
Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability.
Surendra Poudel, D. Kim
semanticscholar   +1 more source

Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways

Frontiers in Neuroscience, 2021
Traumatic brain injury (TBI) results in complex pathological reactions, where the initial lesion is followed by secondary inflammation and edema. Our laboratory and others have reported that angiotensin receptor blockers (ARBs) have efficacy in improving
Peter J Attilio, Dustin Snapper, M. Rusnák, Akira Isaac, A. Soltis, M. Wilkerson, C. Dalgard, A. Symes   +7 more
semanticscholar   +1 more source

Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study

Scientific Reports, 2021
To date, two randomized, controlled studies support the use of candesartan for migraine prophylaxis but with limited external validity. We aim to evaluate the effectiveness and tolerability of candesartan in clinical practice and to explore predictors of
Carmen Sánchez-Rodríguez, Á. Sierra, Álvaro Planchuelo-Gómez, E. Martínez-Pías, Á. Guerrero, D. García‐Azorín   +5 more
semanticscholar   +1 more source

Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol

European Heart Journal, 2016
Aims Contemporary adjuvant treatment for early breast cancer is associated with improved survival but at the cost of increased risk of cardiotoxicity and cardiac dysfunction. We tested the hypothesis that concomitant therapy with the angiotensin receptor
G. Gulati, S. Heck, A. H. Ree, P. Hoffmann, J. Schulz-Menger, Morten Wang Fagerland, B. Gravdehaug, F. von Knobelsdorff-Brenkenhoff, A. Bratland, T. Storås, T. Hagve, H. Røsjø, K. Steine, J. Geisler, T. Omland   +14 more
semanticscholar   +1 more source

Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment

JAMA Network Open, 2020
Key Points Question What are the comparative neurocognitive effects of an angiotensin receptor blocker, candesartan, and an angiotensin-converting enzyme inhibitor, lisinopril, on adults with hypertension and executive mild cognitive impairment? Findings
I. Hajjar, Maureen Okafor, Darius McDaniel, Malik Obideen, Elizabeth Dee, Mahsa Shokouhi, A. Quyyumi, A. Levey, F. Goldstein   +8 more
semanticscholar   +1 more source

Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

Journal of Clinical Investigation, 2021
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high ...
Taisuke Kato, Ri-ichiroh Manabe, H. Igarashi, F. Kametani, S. Hirokawa, Yumi Sekine, N. Fujita, S. Saito, Y. Kawashima, Yuya Hatano, Shoichiro Ando, H. Nozaki, A. Sugai, M. Uemura, M. Fukunaga, Toshiya Sato, A. Koyama, Rie Saito, Atsushi Sugie, Y. Toyoshima, Hirotoshi Kawata, S. Murayama, Masaki Matsumoto, A. Kakita, M. Hasegawa, M. Ihara, M. Kanazawa, M. Nishizawa, S. Tsuji, O. Onodera   +29 more
semanticscholar   +1 more source

The comparison between combination of candesartan-amlodipine and candesartan-furosemide on blood pressure in hypertensive patients with chronic kidney disease [PDF]

, 2022
Chronic renal disease is significantly increased by hypertension. Controlling blood pressure is critical in hypertensive individuals. Patients who have good blood pressure (BP) control can reduce morbidity and mortality. This study aimed to compare blood
Juwita, Dian Ayu, Wati, Yolanda Mayestika, A, Almahdy, Rachmaini, Fitri, Abdillah, Rahmad   +4 more
core   +1 more source

Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential

Drug Delivery, 2020
During the last decades, much attention has been focused on SNEDDS approach to resolve concerns of BCS II class drugs with accentuation on upgrading the solubility and bioavailability. The present hypothesis confirms the theory that SNEDDS can reduce the
R. Verma, D. Kaushik
semanticscholar   +1 more source

Determination of candesartan or olmesartan in hypertensive patient plasma using UPLC-MS/MS

Translational and Clinical Pharmacology, 2021
Candesartan and olmesartan are angiotensin II receptor blockers (ARBs) used for the treatment of hypertension and heart failure. Quantitation methods for candesartan and olmesartan were developed using ultra-high performance liquid chromatography-tandem ...
H. Jeong, Yoshihior Seo, N. Gu, M. Rhee, K. Shin   +4 more
semanticscholar   +1 more source

Candesartan cilexetil in children with hypertension or proteinuria: preliminary data [PDF]

, 2006
The angiotensin II receptor blockers irbesartan and losartan effectively reduce blood pressure and proteinuria in childhood. We were impressed by the neutral taste and the small size of the candesartan cilexetil tablets.
Bianchetti, Mario G, Rizzi, Mattia, Simonetti, Giacomo D, Giacomo D. Simonetti, Emilio Fossali, von Vigier, Rodo O, Mattia Rizzi, Rodo O. von Vigier, Mario G. Bianchetti, Konrad, Martin, Fossali, Emilio, Martin Konrad   +11 more
core   +1 more source