The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes [PDF]
Nature Communications, 2018 Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper +2 more
exaly +17 more sources
The hyphal-specific toxin candidalysin promotes fungal gut commensalism [PDF]
NatureThe fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to ...
Tim B Schille +2 more
exaly +7 more sources
Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
doaj +9 more sources
Global fungal-host interactome mapping identifies host targets of candidalysin [PDF]
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Wan-xing Xu, Ruixin Zhu, K A Eruslanova
exaly +5 more sources
Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells [PDF]
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Don N Wickramasinghe +2 more
exaly +11 more sources
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Xuexin Yang +2 more
exaly +13 more sources
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
doaj +7 more sources
Fungal burden, dimorphic transition and candidalysin: Role in Candida albicans-induced vaginal cell damage and mitochondrial activation in vitro. [PDF]
PLoS ONECandida albicans (C. albicans) can behave as a commensal yeast colonizing the vaginal mucosa, and in this condition is tolerated by the epithelium. When the epithelial tolerance breaks down, due to C.
Luca Spaggiari +8 more
doaj +6 more sources
Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide.
PLoS ONE, 2022 Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays a crucial role in C. albicans pathogenesis in the oral cavity and vagina.
Taiki Mori +3 more
doaj +5 more sources
Fungal Toxins and Host Immune Responses [PDF]
Frontiers in Microbiology, 2021 Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce ...
Rhys Brown +3 more
doaj +4 more sources