Host targets of candidalysin. [PDF]
PLoS PathogensCandida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C.
Jianfeng Lin, Scott G Filler
doaj +6 more sources
Global fungal-host interactome mapping identifies host targets of candidalysin [PDF]
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Tian-Yi Zhang +24 more
doaj +6 more sources
Candidalysin biology and activation of host cells [PDF]
mBioCandida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal +8 more
doaj +6 more sources
The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins [PDF]
Cell Death DiscoveryThe common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca2+-dependent mechanisms, such as microvesicle shedding and annexin recruitment to resist ...
Roshan Thapa +5 more
doaj +5 more sources
The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection [PDF]
mBioCandida albicans is one of the most common fungal pathogens, yet much remains unknown about how its virulence factors cooperate to promote pathogenicity. To investigate this, CRISPR-Cas9 technology was used to create a panel of 19 single, double, triple,
Olivia K. A. Paulin +13 more
doaj +3 more sources
Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen +3 more
doaj +5 more sources
Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses [PDF]
Infection and ImmunityExtracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Sejeong Lee +12 more
doaj +3 more sources
Discovery of the High-Affinity Aptamer for Candidalysin Using a Dual-Mode Colorimetric–SERS Platform [PDF]
BiosensorsCandida albicans poses significant health risks through its virulent peptide toxin Candidalysin. As no existing therapeutics specifically target this toxin, developing high-affinity aptamers for its efficient and safe removal is urgently needed.
Yige Sun +8 more
doaj +4 more sources
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis [PDF]
mBioCandida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine +16 more
doaj +3 more sources
The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence [PDF]
Toxins, 2020 The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König +2 more
doaj +2 more sources