Results 101 to 110 of about 1,624 (196)

Augmented Enterocyte Damage During Candida albicans and Proteus mirabilis Coinfection

Frontiers in Cellular and Infection Microbiology, 2022
The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally
Maria Joanna Niemiec, Maria Joanna Niemiec, Mario Kapitan, Mario Kapitan, Maximilian Himmel, Kristina Döll, Thomas Krüger, Tobias G. Köllner, Isabel Auge, Franziska Kage, Christopher J. Alteri, Harry L.T. Mobley, Tor Monsen, Susanne Linde, Sandor Nietzsche, Olaf Kniemeyer, Axel A. Brakhage, Axel A. Brakhage, Ilse D. Jacobsen, Ilse D. Jacobsen, Ilse D. Jacobsen   +20 more
doaj   +1 more source

Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping [PDF]

, 2016
This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. We are grateful to microbiology colleagues throughout Scotland for clinical isolates collection.Peer reviewedPublisher ...
Abeln, Sanne, Brandt, Bernd W., Burgess, Karl V, Heringa, Jaap, Jones, Brian L., Kean, Ryan, May, Ali, Munro, Carol A., Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +11 more
core   +4 more sources

Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis

Molecular Microbiology, EarlyView.
Candida albicans is a major fungal pathogen whose virulence is linked to filamentation. Its close relative, C. dubliniensis, filaments less efficiently and causes disease more rarely. To explore regulatory differences, we created C. dubliniensis mutants lacking transcription regulator orthologs that have been associated with filamentation in C ...
Teresa Meza‐Davalos, Luis F. García‐Ortega, Eugenio Mancera   +2 more
wiley   +1 more source

Medical mycology and fungal immunology : new research perspectives addressing a major world health challenge [PDF]

, 2016
N.A.R.G. is supported by grants from The Wellcome Trust and MRC. M.G.N. is supported by an ERC consolidator grant (no.
Brown GD, Jenkinson HF, Kennedy MJ, Mihai G. Netea, Neil A. R. Gow, Romani L, Van der Graaf CA   +6 more
core   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Pathophysiological microenvironments in oral candidiasis

APMIS, Volume 132, Issue 12, Page 956-973, December 2024.
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC.
Mette Rose Jørgensen
wiley   +1 more source

The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study

Galician Medical Journal
Introduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
doaj   +1 more source

Cortactin: A major cellular target of viral, protozoal, and fungal pathogens

Molecular Microbiology, Volume 122, Issue 2, Page 165-183, August 2024.
Recent advances in research on various viral, protozoal, and fungal pathogens have deepened our understanding of microbial virulence strategies and human disease development. Cortactin, a key host protein involved in actin cytoskeletal dynamics, has emerged as crucial player in host–microbe interactions, with pathogens manipulating its expression and ...
Irshad Sharafutdinov, Barbara Friedrich, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Face/Off: The Interchangeable Side of Candida Albicans [PDF]

, 2020
Due to limited mobility, fungi, like most unicellular organisms, have evolved mechanisms to adapt to sudden chemical and/or physical variation in their environment.
Cottier, Fabien, Hall, Rebecca A.
core   +2 more sources