Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho +18 more
doaj +12 more sources
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
doaj +9 more sources
Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
doaj +7 more sources
Variations in candidalysin amino acid sequence influence toxicity and host responses [PDF]
mBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Don N. Wickramasinghe +14 more
doaj +7 more sources
Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin. [PDF]
Nat MicrobiolCandidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR screen in the TR146 human oral epithelial cell line and identified that disruption of genes (XYLT2, B3GALT6 and B3GAT3) in glycosaminoglycan
Lin J +16 more
europepmc +8 more sources
Evaluating the Role of Candida albicans as a Potential Oral Carcinogen [PDF]
Interdisciplinary Perspectives on Infectious DiseasesOral cavity cancers, especially oral squamous cell carcinoma (OSCC), are a major subset of head and neck malignancies. Increasing evidence indicates that oral microbiota, particularly Candida albicans (C.
Fatemeh Amirinia +3 more
doaj +3 more sources
Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model [PDF]
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli, Karla Queiroz
doaj +4 more sources
Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]
Infection and Immunity, 2017 ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women.
Jonathan P. Richardson +9 more
core +8 more sources
EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]
VirulenceCandida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson +6 more
doaj +6 more sources
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes [PDF]
Nature Communications, 2018 Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging
Lydia Kasper +10 more
doaj +9 more sources