Results 11 to 20 of about 635 (146)
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli, Karla Queiroz
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The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence [PDF]
Toxins, 2020 The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König +2 more
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Variations in candidalysin amino acid sequence influence toxicity and host responses
mBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Don N. Wickramasinghe +14 more
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EMBO reports, Volume 24, Issue 11, 06 November 2023., 2023 The cytolytic peptide toxin candidalysin is secreted by the invasive hyphal form of the human fungal pathogen Candida albicans. This study investigates the intricate interaction of candidalysin and neutrophils. Abstract The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs ...
Lucas Unger +12 more
wiley +6 more sources
Candidalysin triggers epithelial cellular stresses that induce necrotic death [PDF]
Cellular Microbiology, 2021 Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage.
Mariana Blagojevic +2 more
exaly +8 more sources
Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]
Nature, 2016 Published by Macmillan28177 ...
David L Moyes +2 more
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mBioCandida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine +16 more
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The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways [PDF]
Cell Reports, 2022 The egress of Candida hyphae from macrophages facilitates immune evasion, but it also alerts macrophages to infection and triggers inflammation. To better define the mechanisms, here we develop an imaging assay to directly and dynamically quantify hyphal escape and correlate it to macrophage responses.
Ana Traven
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Candidalysin Is the Hemolytic Factor of Candida albicans
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
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Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen +3 more
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