Candidalysin biology and activation of host cells [PDF]
mBioCandida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal +8 more
doaj +11 more sources
Global fungal-host interactome mapping identifies host targets of candidalysin [PDF]
Nature CommunicationsCandidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped.
Wan-xing Xu, Ruixin Zhu, K A Eruslanova
exaly +8 more sources
The hyphal-specific toxin candidalysin promotes fungal gut commensalism [PDF]
NatureThe fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to ...
Tim B Schille +2 more
exaly +10 more sources
Variations in candidalysin amino acid sequence influence toxicity and host responses [PDF]
mBioCandida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host ...
Don N. Wickramasinghe +14 more
doaj +9 more sources
Fungal burden, dimorphic transition and candidalysin: Role in Candida albicans-induced vaginal cell damage and mitochondrial activation in vitro. [PDF]
PLoS ONECandida albicans (C. albicans) can behave as a commensal yeast colonizing the vaginal mucosa, and in this condition is tolerated by the epithelium. When the epithelial tolerance breaks down, due to C.
Luca Spaggiari +8 more
doaj +7 more sources
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor [PDF]
Nature Communications, 2019 Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Xuexin Yang +2 more
exaly +14 more sources
Candidalysin Is the Hemolytic Factor of Candida albicans [PDF]
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
doaj +5 more sources
Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model [PDF]
ToxinsCandida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract of healthy humans. Under certain conditions, it can become invasive and cause life-threatening systemic infections.
Moran Morelli, Karla Queiroz
doaj +5 more sources
Host targets of candidalysin. [PDF]
PLoS PathogensCandida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C.
Jianfeng Lin, Scott G Filler
doaj +5 more sources
Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin. [PDF]
Nat MicrobiolCandidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive.
Lin J +16 more
europepmc +7 more sources