Candidalysin Is the Hemolytic Factor of Candida albicans
Toxins, 2022 Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero +11 more
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Candidalysin triggers epithelial cellular stresses that induce necrotic death [PDF]
Cellular Microbiology, 2021 Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage.
Mariana Blagojevic +6 more
openaire +8 more sources
The hyphal-specific toxin candidalysin promotes fungal gut commensalism [PDF]
NatureThe fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C.
Shen-Huan Liang +19 more
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Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection [PDF]
The Journal of Infectious Diseases, 2019 AbstractBackgroundCandidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or ...
Marc Swidergall +9 more
core +10 more sources
Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide.
PLoS ONE, 2022 Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays a crucial role in C. albicans pathogenesis in the oral cavity and vagina.
Taiki Mori +3 more
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Mucosal immune response modulated by secreted and membrane-bound hydrolases of Candida albicans in vulvovaginal candidiasis [PDF]
Frontiers in Fungal BiologyVulvovaginal candidiasis (VVC) affects the physical and mental health of millions of women worldwide. The leading cause of VVC, Candida albicans, can induce a strong mucosal inflammatory reaction during the VVC infection, where secreted and membrane ...
Guocheng Qian +4 more
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مجلة بغداد للعلوم, 2023 Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A. S. Al-Qaysi +1 more
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The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study [PDF]
Galician Medical JournalIntroduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
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Fungal Toxins and Host Immune Responses [PDF]
Frontiers in Microbiology, 2021 Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce ...
Rhys Brown +3 more
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Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]
VirulenceVulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray +6 more
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