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mBio, 2018 Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson +19 more
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Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins, 2022 The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso +10 more
doaj +3 more sources
The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis [PDF]
Journal of Oral Pathology & Medicine, 2020 Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection.
Abdul Wahab, Ridhwan +8 more
core +5 more sources
EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]
VirulenceCandida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson +6 more
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Augmented Enterocyte Damage During Candida albicans and Proteus mirabilis Coinfection [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally
Maria Joanna Niemiec +20 more
doaj +3 more sources
Candidalysin impedes the development of embryonic zebrafish (Danio rerio) [PDF]
, 2021 Abstract Candidalysin is a cytolytic peptide secreted by Candida albicans, an opportunistic human fungal pathogen that was widely spread in clinic and in the environment. However, its impacts on the development of aquatic organisms remain limited.
Jing Shen +7 more
openalex +3 more sources
Indian Journal of Dental ResearchBackground: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani +4 more
doaj +2 more sources
Hyphal‐associated protein expression is crucial for Candida albicans ‐induced eicosanoid biosynthesis in immune cells [PDF]
European Journal of Immunology, Volume 54, Issue 3, March 2024.Candida albicans causes opportunistic infections ranging from mucosal mycoses to life‐threatening systemic infections in immunocompromised patients. During C.
Brunner, Elena +5 more
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Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection [PDF]
The Journal of Infectious Diseases, 2019 Background Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis.
Drummond, R.A. +9 more
core +6 more sources
Membrane Activity of the Fungal Peptide Toxin Candidalysin [PDF]
Biophysical Journal, 2018 Christian Nehls +7 more
openalex +3 more sources