Mucosal immune response modulated by secreted and membrane-bound hydrolases of Candida albicans in vulvovaginal candidiasis [PDF]
Frontiers in Fungal BiologyVulvovaginal candidiasis (VVC) affects the physical and mental health of millions of women worldwide. The leading cause of VVC, Candida albicans, can induce a strong mucosal inflammatory reaction during the VVC infection, where secreted and membrane ...
Guocheng Qian +4 more
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مجلة بغداد للعلوم, 2023 Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A. S. Al-Qaysi +1 more
doaj +3 more sources
Processing of
mBio, 2018 Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson +19 more
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Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins, 2022 The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso +10 more
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Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin. [PDF]
Nat MicrobiolCandidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR screen in the TR146 human oral epithelial cell line and identified that disruption of genes (XYLT2, B3GALT6 and B3GAT3) in glycosaminoglycan
Lin J +16 more
europepmc +5 more sources
Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by
mBio, 2019 Candida albicans is an opportunistic fungal pathogen that can cause life-threatening infections, particularly in immunocompromised patients. C. albicans induced activation of the Nlrp3 inflammasome, leading to secretion of bioactive interleukin 1β (IL-1β)
Ona Rogiers +6 more
doaj +5 more sources
Mucosal passive immunization with monoclonal antibodies targeting Candidalysin and Hyr proteins attenuates vaginal candidiasis in mice [PDF]
VirulenceVulvovaginal candidiasis (VVC) is a prevalent fungal infection primarily caused by the opportunistic pathogen Candida albicans. Among women affected by VVC, up to 8% experience more than four episodes per year, regarded as recurrent vulvovaginal ...
Julie Auffray +6 more
doaj +2 more sources
PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]
PLoS ONEThe fundamental molecules of life are polymers. Prominent examples include nucleic acids and proteins, both of which exhibit a large array of mechanical properties and three-dimensional shapes. The bending rigidity of individual polymers is quantified by
Elizabeth A Conley +6 more
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The pathogenicity and future treatment strategies of Candida albicans [PDF]
Frontiers in Cellular and Infection MicrobiologyCandida albicans (C. albicans) is a major pathogenic fungus that severely impacts on human health. This review systematically elaborates on the key pathogenic processes of C.
Jiadi Wu +6 more
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Candidalysin Drives C. albicans-Induced Allergic Airway Disease Through Platelets [PDF]
Journal of Allergy and Clinical Immunology, 2020 Yifan Wu +6 more
openalex +3 more sources