Results 31 to 40 of about 1,624 (196)

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

mBio
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine, Paul Rudolph, Axel Dietschmann, Antzela Tsavou, Selene Mogavero, Sejeong Lee, Emily L. Priest, Gaukhar Zhurgenbayeva, Nadja Jablonowski, Sandra Timme, Christian Eggeling, Stefanie Allert, Edward Dolk, Julian R. Naglik, Marc T. Figge, Mark S. Gresnigt, Bernhard Hube   +16 more
doaj   +3 more sources

<i>Candida albicans</i> biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses. [PDF]

Infect Immun
Extracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication.
Lee S, Tsavou A, Zarnowski R, Pforte R, Allert S, Krüger T, Kniemeyer O, Brakhage AA, Bui TTT, Andes DR, Richardson JP, Hube B, Naglik JR.   +12 more
europepmc   +3 more sources

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin

Toxins, 2022
The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso, Ana Paula de Araújo Boleti, Patrícia Souza e Silva, Lincoln Takashi Hota Mukoyama, Alexya Sandim Guindo, Luiz Filipe Ramalho Nunes de Moraes, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Cristiano Marcelo Espínola Carvalho, Alinne Pereira de Castro, Ludovico Migliolo   +10 more
doaj   +4 more sources

EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]

Virulence
Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson, Aize Pellon, Nicole O. Ponde, Olivia Hepworth, Lydia F. Daniels Gatward, Julian R. Naglik, David L. Moyes   +6 more
doaj   +5 more sources

Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Indian Journal of Dental Research
Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani, Krishnan Mahalakshmi, Bharathy Jaya, Sankar Leena Sankari, Venkatesan N. Kumar   +4 more
doaj   +3 more sources

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence [PDF]

Toxins, 2020
The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König, Bernhard Hube, Lydia Kasper   +2 more
doaj   +5 more sources

The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins

bioRxiv
The common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells resist other pore-forming toxins by Ca2+ dependent microvesicle shedding and annexins (cholesterol-dependent cytolysins, CDCs), or ...
Thapa R, Kayejo V, Hube B, Naglik JR, Keyel PA.   +4 more
europepmc   +3 more sources

The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways [PDF]

Cell Reports, 2022
Ana Traven
exaly   +3 more sources

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis

PLOS Pathogens
Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces.
Kuo-Yao Tseng, Yu-Tsung Huang, Yu-Ting Huang, Yu-Ting Su, An-Ni Wang, Wen-Yen Weng, Cai-Ling Ke, Yu-Chiao Yeh, Jhih-Jie Wang, Shin-Hei Du, Ziliang Gu, Wei-Lin Chen, Ching-Hsuan Lin, Yu-Huan Tsai   +13 more
semanticscholar   +5 more sources

Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [PDF]

Journal of Biological Chemistry, 2022
Nicole O Ponde, Don N Wickramasinghe, Jonathan P Richardson   +2 more
exaly   +3 more sources