Candidalysin sets off the innate alarm [PDF]
Science Immunology, 2017 Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ + cells during oropharyngeal candidiasis. See the related research article by Verma et al .
Xin Li, Irina Leonardi, Iliyan D. Iliev
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Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival Fibroblasts [PDF]
International Journal of Molecular Sciences, 2023 Candida albicans (Ca) is frequently detected in the peri-implant sulcus with peri-implantitis, a major postoperative complication after oral implant therapy. However, the involvement of Ca in the pathogenesis of peri-implantitis remains unclear. In this study, we aimed to clarify Ca prevalence in the peri-implant sulcus and investigated the effects of ...
Yasufumi Nishikawa +8 more
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Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [PDF]
Journal of Biological Chemistry, 2022 Nicole O Ponde +2 more
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Candidalysin Drives C. albicans-Induced Allergic Airway Disease Through Platelets [PDF]
Journal of Allergy and Clinical Immunology, 2020 Yifan Wu +6 more
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Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome [PDF]
Antimicrobial Agents and Chemotherapy, 2019 Repurposing of currently approved medications is an attractive option for the development of novel treatment strategies against physiological and infectious diseases. The antidiabetic sulfonylurea glyburide has demonstrated off-target capacity to inhibit activation of the NLRP3 inflammasome in a variety of disease models, including vaginal
David J. Lowes +2 more
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Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]
Immunology, 2020 SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho +5 more
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A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis- Associated Strains [PDF]
, 2023 Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to ...
Andrea Ardizzoni +19 more
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Journal of Biological Chemistry, 2022 Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
C. Russell +4 more
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Polymerization mechanism of the Candida albicans virulence factor candidalysin
Journal of Biological ChemistryCandida albicans is a commensal fungus that can cause epithelial infections and life-threatening invasive candidiasis. The fungus secretes candidalysin (CL), a peptide that causes cell damage and immune activation by permeation of epithelial membranes. The mechanism of CL action involves strong peptide assembly into polymers in solution.
Katherine G. Schaefer +5 more
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Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]
Infection and Immunity, 2017 ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women. Despite its prevalence, the fungal factors responsible for initiating symptomatic infection remain poorly understood.
Jonathan P. Richardson +9 more
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