Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells [PDF]
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jemima Ho +5 more
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Beyond colonization: Candida albicans exhibits substantial pathogenic potential in cystic fibrosis environments [PDF]
npj Biofilms and MicrobiomesCystic fibrosis (CF) sputum represents a highly permissive niche for microbial colonization, yet the contribution of Candida albicans to disease progression remains insufficiently investigated despite its frequent detection in CF airways. We hypothesized
Natasa Radakovic +8 more
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Indian Journal of Dental ResearchBackground: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani +4 more
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EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway [PDF]
VirulenceCandida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C.
Ruth E. Dickenson +6 more
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Essential role of hepcidin in host resistance to disseminated candidiasis [PDF]
Cell ReportsSummary: Candida albicans is a leading cause of life-threatening invasive infection despite antifungal therapy. Patients with chronic liver disease are at increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely ...
Tanmay Arekar +13 more
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Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]
Infection and Immunity, 2017 ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women.
Jonathan P. Richardson +9 more
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"Pour some sugar on me"-Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation. [PDF]
PLoS PathogensCandida albicans is an opportunistic fungal pathogen that colonizes mucosal surfaces of most humans. Only in rare cases, C. albicans isolates are found in the environment.
Theresa Lange +12 more
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Candidalysin: discovery and function in Candida albicans infections
Current Opinion in Microbiology, 2019 Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Julian R. Naglik +2 more
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The hyphal-specific toxin candidalysin promotes fungal gut commensalism [PDF]
NatureThe fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C.
Shen-Huan Liang +19 more
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Polymerization mechanism of the Candida albicans virulence factor candidalysin [PDF]
Journal of Biological ChemistryCandida albicans is a commensal fungus that can cause epithelial infections and life-threatening invasive candidiasis. The fungus secretes candidalysin (CL), a peptide that causes cell damage and immune activation by permeation of epithelial membranes. The mechanism of CL action involves strong peptide assembly into polymers in solution.
Katherine G. Schaefer +5 more
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