Results 31 to 40 of about 1,663 (175)

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence [PDF]

mBio, 2018
Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson, Selene Mogavero, David L. Moyes, Mariana Blagojevic, Thomas Krüger, Akash H. Verma, Bianca M. Coleman, Jacinto De La Cruz Diaz, Daniela Schulz, Nicole O. Ponde, Giulia Carrano, Olaf Kniemeyer, Duncan Wilson, Oliver Bader, Simona I. Enoiu, Jemima Ho, Nessim Kichik, Sarah L. Gaffen, Bernhard Hube, Julian R. Naglik   +19 more
doaj   +8 more sources

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin

Toxins, 2022
The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders ...
Pedro Henrique de Oliveira Cardoso, Ana Paula de Araújo Boleti, Patrícia Souza e Silva, Lincoln Takashi Hota Mukoyama, Alexya Sandim Guindo, Luiz Filipe Ramalho Nunes de Moraes, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Cristiano Marcelo Espínola Carvalho, Alinne Pereira de Castro, Ludovico Migliolo   +10 more
doaj   +3 more sources

The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis [PDF]

Journal of Oral Pathology & Medicine, 2020
AbstractOral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer.
Engku Anis Fariha Engku Nasrullah Satiman, Hasna Ahmad, Ahmad Bazli Ramzi, Ridhwan Abdul Wahab, Mohd Arifin Kaderi, Wan Himratul Aznita Wan Harun, Stuart Dashper, Michael McCullough, Mohd Hafiz Arzmi   +8 more
openaire   +5 more sources

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

mBio
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation ...
Marisa Valentine, Paul Rudolph, Axel Dietschmann, Antzela Tsavou, Selene Mogavero, Sejeong Lee, Emily L. Priest, Gaukhar Zhurgenbayeva, Nadja Jablonowski, Sandra Timme, Christian Eggeling, Stefanie Allert, Edward Dolk, Julian R. Naglik, Marc T. Figge, Mark S. Gresnigt, Bernhard Hube   +16 more
doaj   +2 more sources

Beyond colonization: Candida albicans exhibits substantial pathogenic potential in cystic fibrosis environments [PDF]

npj Biofilms and Microbiomes
Cystic fibrosis (CF) sputum represents a highly permissive niche for microbial colonization, yet the contribution of Candida albicans to disease progression remains insufficiently investigated despite its frequent detection in CF airways. We hypothesized
Natasa Radakovic, Nikola Plackic, Jelena Djuris, Joachim Morschhäuser, Aleksandar Sovtic, Mihail Basa, Predrag Minic, Fabio Zobi, Aleksandar Pavic   +8 more
doaj   +2 more sources

Candidalysin Drives C. albicans-Induced Allergic Airway Disease Through Platelets [PDF]

Journal of Allergy and Clinical Immunology, 2020
Yifan Wu, Zhimin Zeng, Yubiao Guo, John Knight, Lynn Bimler, Julian R. Naglik, Bernhard Hube   +6 more
openalex   +3 more sources

Essential role of hepcidin in host resistance to disseminated candidiasis [PDF]

Cell Reports
Summary: Candida albicans is a leading cause of life-threatening invasive infection despite antifungal therapy. Patients with chronic liver disease are at increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely ...
Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia   +13 more
doaj   +2 more sources

Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis [PDF]

Nature Communications
Eosinophils are innate immune cells with central roles in allergy, parasitic diseases and multiple inflammatory conditions. Moreover, their role in host-pathogen interactions has been well characterized.
Ilan Zaffran, Pratibha Gaur, Prince Ofori, Yoav Charpak-Amikam, Hadas Pahima, David Shasha, Nir Osherov, Bernhard Hube, Ronen Ben-Ami, Julian R. Naglik, Ofer Mandelboim, Joana Vitte, Francesca Levi-Schaffer   +12 more
doaj   +2 more sources

Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells [PDF]

Cells, 2020
Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jemima Ho, Don N. Wickramasinghe, Spyridoula-Angeliki Nikou, Bernhard Hube, Jonathan P. Richardson, Julian R. Naglik   +5 more
doaj   +6 more sources

Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Indian Journal of Dental Research
Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).
Mani B. Subramani, Krishnan Mahalakshmi, Bharathy Jaya, Sankar Leena Sankari, Venkatesan N. Kumar   +4 more
doaj   +2 more sources