"Pour some sugar on me"-Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation. [PDF]
PLoS PathogensCandida albicans is an opportunistic fungal pathogen that colonizes mucosal surfaces of most humans. Only in rare cases, C. albicans isolates are found in the environment.
Theresa Lange +12 more
doaj +2 more sources
Candidalysin: discovery and function in Candida albicans infections
Current Opinion in Microbiology, 2019 Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Julian R. Naglik +2 more
openalex +4 more sources
Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival Fibroblasts [PDF]
, 2023 Candida albicans (Ca) is frequently detected in the peri-implant sulcus with peri-implantitis, a major postoperative complication after oral implant therapy. However, the involvement of Ca in the pathogenesis of peri-implantitis remains unclear.
Yasufumi Nishikawa +8 more
openalex +4 more sources
Pectins mitigate Candidalysin-induced gut barrier disruption and inflammation in vitro in a degree of methyl-esterification-dependent manner [PDF]
Food Hydrocolloids for HealthPectin, a dietary fiber, exhibits anti-inflammatory properties influenced by its degree of methyl-esterification (DM). Inflammatory bowel disease (IBD) is characterized by chronic inflammation due to a compromised epithelial barrier, dysregulated ...
Naschla Gasaly +5 more
doaj +3 more sources
Exploring the role of candidalysin in the pathogenicity of Candida albicans by gene set enrichment analysis and evolutionary dynamics. [PDF]
Am J Transl ResZhou X +5 more
europepmc +2 more sources
Polymerization mechanism of the Candida albicans virulence factor candidalysin [PDF]
Journal of Biological ChemistryCandida albicans is a commensal fungus that can cause epithelial infections and life-threatening invasive candidiasis. The fungus secretes candidalysin (CL), a peptide that causes cell damage and immune activation by permeation of epithelial membranes. The mechanism of CL action involves strong peptide assembly into polymers in solution.
Katherine G. Schaefer +5 more
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A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis- Associated Strains [PDF]
, 2023 Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to ...
Andrea Ardizzoni +19 more
core +5 more sources
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease [PDF]
Journal of Hepatology, 2019 Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp.
Huikuan Chu +16 more
openalex +5 more sources
Geniposide attenuates astrocyte pyroptosis in depression via long non-coding RNA Six3os1-mediated regulation of the miR-511-3p/COL9A3 axis and MAPK/NLRP3 signaling. [PDF]
J Cell Commun SignalGeniposide ameliorates depressive‐like behaviors in CUMS mice through the lncRNA Six3os1/miR‐511‐3p/COL9A3 axis and MAPK/NLRP3 signaling pathway. Abstract Depression involves multifaceted molecular pathways, with astrocyte pyroptosis emerging as a critical contributor to neuroinflammation.
Zou T, Mei C, Liang X, Shang X, Duan G.
europepmc +2 more sources
Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin. [PDF]
EMBO Rep, 2023 AbstractThe peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET‐like structures (NLS), which are more compact and less fibrous than canonical NETs.
Unger L +12 more
europepmc +6 more sources