The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease [PDF]
Journal of Hepatology, 2019 Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp.
Huikuan Chu +16 more
openalex +4 more sources
Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.
PLoS Pathogens, 2021 During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall +10 more
doaj +1 more source
The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans [PDF]
, 2023 Purpose of Review The fungus Candida albicans has evolved to live in close association with warm-blooded hosts and is found frequently on mucosal surfaces of healthy humans. As an opportunistic pathogen, C.
Jacobsen, Ilse D.
core +1 more source
Anti-Candida and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis [PDF]
, 2023 Vaginal ecosystem is a unique environment where, in physiological conditions, lactobacilli dominate. However, pathogenic microbial species responsible for vaginitis and vaginosis can also harbor vaginal microbiota. To extend the data published by De Seta
Andrea Ardizzoni +7 more
core +2 more sources
Management of alcoholic hepatitis: A clinical perspective
Liver International, Volume 43, Issue 10, Page 2078-2095, October 2023., 2023 Abstract Alcohol‐associated liver disease is the primary cause of liver‐related mortality worldwide and one of the most common indications for liver transplantation. Alcoholic hepatitis represents the most acute and severe manifestation of alcohol‐associated liver disease and is characterized by a rapid onset of jaundice with progressive inflammatory ...
Philipp Kasper +3 more
wiley +1 more source
The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage [PDF]
, 2016 Funding: Our own work was funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust ISSF (RG12723-14), the MRC and University of Aberdeen (MR/N006364/1) (DW); Medical Research ...
Hube, Bernhard +2 more
core +2 more sources
Ahr1-dependent regulation of ECE1 and other core filamentation response genes in Candida albicans [PDF]
, 2020 Candida albicans is a normally harmless commensal fungus and part of the human microbiota. However, in immunocompromised patients, C. albicans can cause diseases ranging from superficial infections to life threatening systemic infections.
Ruben, Sophia
core +1 more source
Alcohol, the gut microbiome, and liver disease
Journal of Gastroenterology and Hepatology, Volume 38, Issue 8, Page 1205-1210, August 2023., 2023 Abstract The microorganisms inhabiting our gastrointestinal tract are critical for human health. Chronic heavy alcohol use can modulate the composition and function of the gut microbiota, thereby exacerbating end‐organ damage via the gut–brain axis and the gut–liver axis.
Michael H Jew, Cynthia L Hsu
wiley +1 more source
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives [PDF]
, 2021 Candida; Antifungal immunity; MicrobiotaCándida; Inmunidad antimicótica; MicrobiotaCàndida; Immunitat antifúngica; MicrobiotaCandida albicans is a major fungal pathogen of humans.
Alaban, Leovigildo-Rey +6 more
core +6 more sources
Oral Fungal Alterations in Patients with COVID‐19 and Recovered Patients
Advanced Science, Volume 10, Issue 19, July 6, 2023., 2023 This research characterizes oral mycobiome in coronavirus disease 2019 (COVID‐19) patients and recovered COVID‐19 patients, constructs and validates the diagnostic model for COVID‐19, successfully diagnoses suspected cases with positive immunoglobulin G antibody as confirmed patients, and depicts the correlations between the oral microbiome and ...
Xiaobo Hu +13 more
wiley +1 more source