Results 41 to 50 of about 1,624 (196)
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins [PDF]
mBio, 2022 Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems.
Jonathan P. Richardson +18 more
doaj +5 more sources
Fungal Toxins and Host Immune Responses [PDF]
Frontiers in Microbiology, 2021 Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce ...
Rhys Brown +3 more
doaj +4 more sources
The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. [PDF]
Journal of Hepatology, 2020 Alcohol-associated liver disease is a leading indication for liver transplantation and a leading cause of mortality. Alterations to the gut microbiota contribute to the pathogenesis of alcohol-associated liver disease. Patients with alcohol-associated liver disease have increased proportions of Candida spp.
H. Chu +16 more
semanticscholar +5 more sources
Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 The incidence of systemic fungal infection is increasing, and millions of people around the world suffer from fungal infections. Candida albicans is one of the most frequently isolated fungal pathogens in clinical settings. As a polymorphic organism, the
Yao-Qi Chen +3 more
doaj +4 more sources
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis [PDF]
Cell Reports, 2023 Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu +19 more
doaj +2 more sources
Journal of Biological Chemistry, 2022 Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
Charles M Russell +4 more
semanticscholar +4 more sources
Baghdad Science Journal, 2023 Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal ...
Safaa A S Al-Qaysi +1 more
semanticscholar +3 more sources
Sekretionsmechanismus des Pilztoxins Candidalysin entschlüsselt [PDF]
BIOspektrumFlorian Altegoer
semanticscholar +3 more sources
The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis [PDF]
Journal of Oral Pathology & Medicine, 2020 Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection.
Abdul Wahab, Ridhwan +8 more
core +5 more sources
eLife, 2022 Candida albicans causes severe invasive candidiasis. C. albicans infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, the mechanism that CL uses to permeabilize membranes is unclear.
Charles M Russell +12 more
doaj +2 more sources