Results 51 to 60 of about 1,624 (196)

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence [PDF]

mBio, 2018
Candida albicans is an opportunistic fungal pathogen responsible for superficial and life-threatening infections in humans. During mucosal infection, C. albicans undergoes a morphological transition from yeast to invasive filamentous hyphae that secrete ...
Jonathan P. Richardson, Selene Mogavero, David L. Moyes, Mariana Blagojevic, Thomas Krüger, Akash H. Verma, Bianca M. Coleman, Jacinto De La Cruz Diaz, Daniela Schulz, Nicole O. Ponde, Giulia Carrano, Olaf Kniemeyer, Duncan Wilson, Oliver Bader, Simona I. Enoiu, Jemima Ho, Nessim Kichik, Sarah L. Gaffen, Bernhard Hube, Julian R. Naglik   +19 more
doaj   +8 more sources

Candida Infections: The Role of Saliva in Oral Health—A Narrative Review [PDF]

Microorganisms
Candida species, particularly Candida albicans, are causative agents of oral infections to which immunocompromised patients are especially susceptible.
Riyoko Tamai, Yusuke Kiyoura
doaj   +2 more sources

Essential role of hepcidin in host resistance to disseminated candidiasis [PDF]

Cell Reports
Summary: Candida albicans is a leading cause of life-threatening invasive infection despite antifungal therapy. Patients with chronic liver disease are at increased risk of candidemia, but the mechanisms underlying this susceptibility are incompletely ...
Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia   +13 more
doaj   +2 more sources

Virulence factor candidalysin impairs epithelial barrier integrity and initiates inflammation in a gut-on-chip model

bioRxiv
Candida albicans is an opportunistic pathogenic yeast commonly found in the gastrointestinal tract, vagina, and oral cavity of healthy humans. Under certain conditions, it can become invasive, causing mucosal or life-threatening systemic infections.
Moran Morelli, Karla Queiroz
semanticscholar   +2 more sources

Quantification of biophysical properties of candidalysin, a fungal peptide toxin secreted by C. albicans during invasion. [PDF]

Biophysical Journal, 2023
Gaukhar Zhurgenbayeva, C. Eggeling
semanticscholar   +2 more sources

Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans

Cellular Microbiology, 2021
The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections. Although the ability to transition from the yeast to the hypha morphology is essential for virulence, hypha formation and host cell invasion per se are not sufficient
S. Mogavero, F. M. Sauer, S. Brunke, Stefanie Allert, Daniel Schulz, Stephanie Wisgott, N. Jablonowski, Osama Elshafee, Thomas Krüger, O. Kniemeyer, A. Brakhage, J. Naglik, E. Dolk, B. Hube   +13 more
semanticscholar   +6 more sources

Candidalysin impedes the development of embryonic zebrafish (Danio rerio) [PDF]

, 2021
Abstract Candidalysin is a cytolytic peptide secreted by Candida albicans, an opportunistic human fungal pathogen that was widely spread in clinic and in the environment. However, its impacts on the development of aquatic organisms remain limited.
Jing Shen, JingCong Tan, Haochun Shi, Jie Zhou, Yanbin Zhao, Kun Zhang, Ning-Ning Liu, Hui Wang   +7 more
openalex   +3 more sources

The P-type calcium pump Spf1 regulates immune response by maintenance of the endoplasmic reticulum-plasma membrane contacts during Candida albicans systemic infection [PDF]

Mycology
Spf1 is an important P-type ATPase in Candida albicans, which functions as an endoplasmic reticulum calcium pump to maintain calcium homoeostasis. The deficiency of Spf1 attenuates the virulence of C. albicans.
Yuchao Ji, Dou Chen, Menglin Shao, Zhuo Liu, Mingchun Li, Qilin Yu   +5 more
doaj   +2 more sources

Candida albicans epithelial invasion induces host membrane rupture at distinct subcellular niches following priming by the fungal toxin candidalysin

bioRxiv
Candida albicans is an opportunistic fungal pathogen normally found as a commensal in human mucosa. In susceptible patients, its hyphal filamentous form can invade and damage host epithelium leading to local or systemic infection.
Noa Conan, Laura Marthe, Anouck Shekoory, Patricia Latour-Lambert, J. Franetich, Martin Larsen, Allon Weiner   +6 more
semanticscholar   +2 more sources

Membrane Activity of the Fungal Peptide Toxin Candidalysin [PDF]

Biophysical Journal, 2018
Christian Nehls, Julia Wernecke, Laura Paulowski, Mareike Lewke, Helena S. Fabritz, Julian R. Naglik, Bernhard Hube, Thomas Gutsmann   +7 more
openalex   +3 more sources