Results 51 to 60 of about 1,663 (175)

Candidalysin is a fungal peptide toxin critical for mucosal infection [PDF]

Nature, 2016
Published by Macmillan28177 ...
David L. Moyes, Duncan Wilson, Jonathan P. Richardson, Selene Mogavero, Shirley X. Tang, Julia Wernecke, Sarah Höfs, Remi L. Gratacap, Jon Robbins, Manohursingh Runglall, Celia Murciano, Mariana Blagojevic, Selvam Thavaraj, Toni M. Förster, Betty Hebecker, Lydia Kasper, Gema Vizcay, Simona I. Iancu, Nessim Kichik, Antje Häder, Oliver Kurzai, Ting Luo, Thomas Krüger, Olaf Kniemeyer, Ernesto Cota, Oliver Bader, Robert T. Wheeler, Thomas Gutsmann, Bernhard Hube, Julian R. Naglik   +29 more
openalex   +10 more sources

Candidalysin sets off the innate alarm [PDF]

Science Immunology, 2017
Candidalysin-induced epithelial cell damage promotes expansion of innate TCRαβ + cells during oropharyngeal candidiasis. See the related research article by Verma et al .
Xin Li, Irina Leonardi, Iliyan D. Iliev
openaire   +2 more sources

Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis

Cell Reports, 2023
Summary: The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer’s disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry   +19 more
doaj   +1 more source

Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]

Immunology, 2020
SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho, Giorgio Camilli, James S. Griffiths, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik   +5 more
openaire   +3 more sources

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

PLoS Pathogens, 2021
During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall, Norma V Solis, Nicolas Millet, Manning Y Huang, Jianfeng Lin, Quynh T Phan, Michael D Lazarus, Zeping Wang, Michael R Yeaman, Aaron P Mitchell, Scott G Filler   +10 more
doaj   +1 more source

Commensal colonization of <i>Candida albicans</i> in the mouse gastrointestinal tract is mediated via expression of candidalysin and adhesins. [PDF]

Microbiol Spectr
Mauk KE, Miramón P, Lorenz MC, Lortal L, Naglik JR, Hube B, Bimler L, Kheradmand F, Corry DB.   +8 more
europepmc   +2 more sources

Candida Albicans Elicits Protective Allergic Responses Via Platelet Mediated T helper 2 and T helper 17 Cell Polarization [PDF]

, 2021
Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood.
Bimler, Lynn, Chang, Cheng-yen, Corry, David B., Cruz, Miguel A., Guo, Yubiao, Huang, Xinyan, Hube, Bernhard, Kheradmand, Farrah, Knight, John M., Luong, Amber U., Naglik, Julian R., Song, Lizhen, Sun, Hua, Valladolid, Christian, Weatherhead, Jill E., Wu, Yifan, Zeng, Yuying, Zeng, Zhimin   +17 more
core   +3 more sources

Alcohol-Related Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions. [PDF]

MedComm (2020)
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Tan Y, Hu Y, Yang Y, Chu H.
europepmc   +2 more sources

Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis

PLOS Pathogens
Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.
Kuo-Yao Tseng, Yu‐Tsung Huang, Yuting Huang, Yuting Su, An-Ni Wang, Wen-Yen Weng, Cai-Ling Ke, Yu-Chiao Yeh, Jhih-Jie Wang, Shin-Hei Du, Zi-Qi Gu, Weilin Chen, C.C. Lin, Yu-Huan Tsai   +13 more
openalex   +4 more sources

Candidalysin impedes the development of embryonic zebrafish (Danio rerio) [PDF]

, 2021
Abstract Candidalysin is a cytolytic peptide secreted by Candida albicans, an opportunistic human fungal pathogen that was widely spread in clinic and in the environment. However, its impacts on the development of aquatic organisms remain limited.
Jing Shen, JingCong Tan, Haochun Shi, Jie Zhou, Yanbin Zhao, Kun Zhang, Ning-Ning Liu, Hui Wang   +7 more
openaire   +1 more source