Results 61 to 70 of about 1,624 (196)

Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection [PDF]

The Journal of Infectious Diseases, 2019
Background Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis.
Drummond, R.A., Filler, S.G., Hube, B., Khalaji, M., Lionakis, M.S., Moyes, D.L., Murdoch, C., Naglik, J.R., Solis, N.V., Swidergall, M.   +9 more
core   +7 more sources

Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin

Mucosal Immunology
Dylan Launder, John T. Dillon, Leah M. Wuescher, Trevor Glanz, Nora Abdul-Aziz, Elise Mein-Chiain Yi, J. Naglik, Randall G. Worth, H. Conti   +8 more
semanticscholar   +2 more sources

Polymers of the candidalysin peptide become membrane pores.

Biophysical Journal, 2023
Charles M Russell, K. G. Schaefer, A. Dixson, Amber L H Gray, Robert J Pyron, Ryan J Schuck, D. S. Alves, Thanh Do, Gavin King, F. Barrera   +9 more
semanticscholar   +2 more sources

Candidalysin Drives C. albicans-Induced Allergic Airway Disease Through Platelets [PDF]

Journal of Allergy and Clinical Immunology, 2020
Yifan Wu, Zhimin Zeng, Yubiao Guo, John Knight, Lynn Bimler, Julian R. Naglik, Bernhard Hube   +6 more
openalex   +3 more sources

Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Repurposing of currently approved medications is an attractive option for the development of novel treatment strategies against physiological and infectious diseases. The antidiabetic sulfonylurea glyburide has demonstrated off-target capacity to inhibit activation of the NLRP3 inflammasome in a variety of disease models, including vaginal
David J. Lowes, Kirk E. Hevener, Brian M. Peters   +2 more
openalex   +5 more sources

A New Phenotype in Candida-Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis- Associated Strains [PDF]

, 2023
Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal to ...
Andrea Ardizzoni, Antonella Lupetti, Arianna Sala, Arianna Tavanti, Axel A. Brakhage, Benjamin L. King, Claudio Cermelli, Cosmeri Rizzato, Elisabetta Blasi, Eva Pericolini, Francesco de Seta, Jane van der Schaaf, Luca Spaggiari, Manola Comar, Maximilian Himmel, Nikhil Vaidya, Olaf Kniemeyer, Robert T. Wheeler, Selene Mogavero, Thomas Krüger   +19 more
core   +5 more sources

Candida albicans and candidalysin in inflammatory disorders and cancer [PDF]

Immunology, 2020
SummaryAs our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C.
Jemima Ho, Giorgio Camilli, James S. Griffiths, Jonathan P. Richardson, Nessim Kichik, Julian R. Naglik   +5 more
openaire   +4 more sources

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

PLoS Pathogens, 2021
During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection.
Marc Swidergall, Norma V Solis, Nicolas Millet, Manning Y Huang, Jianfeng Lin, Quynh T Phan, Michael D Lazarus, Zeping Wang, Michael R Yeaman, Aaron P Mitchell, Scott G Filler   +10 more
doaj   +1 more source

Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa [PDF]

Infection and Immunity, 2017
ABSTRACT Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans , is a disease of immunocompetent and otherwise healthy women. Despite its prevalence, the fungal factors responsible for initiating symptomatic infection remain poorly understood.
Jonathan P. Richardson, Hubertine M. E. Willems, David L. Moyes, Saeed Shoaie, Katherine S. Barker, Shir Lynn Tan, Glen E. Palmer, Bernhard Hube, Julian R. Naglik, Brian M. Peters   +9 more
openalex   +6 more sources

The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways

Science Signaling, 2022
The fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK ...
Spyridoula-Angeliki Nikou, Chunsheng Zhou, James S. Griffiths, N. Kotowicz, Bianca M. Coleman, Mary J. Green, D. Moyes, S. Gaffen, J. Naglik, P. Parker   +9 more
semanticscholar   +1 more source