Results 61 to 70 of about 1,118 (147)

Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

mBio, 2018
Life-threatening systemic infections often occur due to the translocation of pathogens across the gut barrier and into the bloodstream. While the microbial and host mechanisms permitting bacterial gut translocation are well characterized, these ...
Stefanie Allert, Toni M. Förster, Carl-Magnus Svensson, Jonathan P. Richardson, Tony Pawlik, Betty Hebecker, Sven Rudolphi, Marc Juraschitz, Martin Schaller, Mariana Blagojevic, Joachim Morschhäuser, Marc Thilo Figge, Ilse D. Jacobsen, Julian R. Naglik, Lydia Kasper, Selene Mogavero, Bernhard Hube   +16 more
doaj   +1 more source

It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With Candida Virulence, Triggers VVC Onset

Frontiers in Microbiology, 2021
Vulvovaginal candidiasis (VVC) is a symptomatic inflammation of the vagina mainly caused by C. albicans. Other species, such as C. parapsilosis, C. glabrata, C. tropicalis, and C. krusei, are mainly associated to the recurrent form of the disease (RVVC),
Andrea Ardizzoni, Robert T. Wheeler, Robert T. Wheeler, Eva Pericolini, Eva Pericolini   +4 more
doaj   +1 more source

Research Progress in the Treatment of Vaginitis With Bioactive Compounds: Targeting of Vaginal Microflora

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Mechanism diagram of the effect of herbal medicine on vaginitis. Herbal medicines mainly combat vaginitis by (A) inhibiting bacteria, (B) inhibiting fungi, (C) acting on the cilia of Trichomonas, (D) inhibiting virus replication, (E) repairing the mucosa, (F) enhancing immunity, and (G) maintaining the microecological balance.
Yongming Li, Huiyu Liu, Ruihan Li, Rong Li, Jiaqi Liu   +4 more
wiley   +1 more source

Taste Dysfunction in Oral Candidiasis: Impact of Candida Carriage and Hyphal Presence

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Taste dysfunction is a common symptom of oral candidiasis; however, its underlying mechanisms remain unclear. Objectives This study aimed to determine whether Candida albicans carriage, particularly its hyphal phenotype, is associated with impaired taste sensitivity.
Younjung Park, Hyo‐Jung Jung, Sin Hye Hwang, Eunae Sandra Cho, Hyung‐Joon Ahn   +4 more
wiley   +1 more source

Candida albicans Cells Lacking AP‐2 Have Defective Hyphae and Are Avirulent Despite Increased Host Uptake and Intracellular Proliferation in Macrophages

Molecular Microbiology, Volume 125, Issue 1, Page 1-12, January 2026.
Mutation of exocytic cargo adapter apm4Δ/Δ results in reduced virulence of Candida albicans during infection despite promoting intracellular growth in macrophages. ABSTRACT Candida albicans is a commensal microbe and opportunistic human pathogen. Candida yeast are recognized and taken up by macrophages via phagocytosis.
Stella Christou, Shannon Evans, Harriet Knafler, Iwona Smaczynska‐de Rooij, Kathryn R. Ayscough, Simon A. Johnston   +5 more
wiley   +1 more source

Detection of Cytolysis Peptide Toxin Gene (Candidalysin) in Candida albicans Isolates

Indian Journal of Public Health Research & Development, 2019
This study was launched to identify the presence of the gene; ece1 (extent of cell elongation 1), encodes for a precursor protein related to the candidalysin, a cytolytic peptide toxin important for the induction of mucosal-related infections, in isolates of Candida albicans. Initially, 30 isolates of C.
S. Al-Zubaidi
openalex   +2 more sources

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome [PDF]

Antimicrobial Agents and Chemotherapy, 2020
Repurposing of currently approved medications is an attractive option for the development of novel treatment strategies against physiological and infectious diseases. The antidiabetic sulfonylurea glyburide has demonstrated off-target capacity to inhibit activation of the NLRP3 inflammasome in a variety of disease models, including vaginal
David J, Lowes, Kirk E, Hevener, Brian M, Peters   +2 more
openaire   +2 more sources

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

Journal of Biological Chemistry, 2023
Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
Charles M. Russell, Jennifer A. Rybak, Jian Miao, Brian M. Peters, Francisco N. Barrera   +4 more
openaire   +2 more sources

The Cytotoxic Effect of Candidalysin on Primary Human Gingival Fibroblasts: An In Vitro Study

Galician Medical Journal
Introduction. This study aimed to investigate the cytotoxic and functional effects of candidalysin, a cytolytic peptide toxin produced by Candida albicans, on primary human gingival fibroblasts (hGFs). Methods.
Elham Alsahafi, Abdel-Rahman Youssef
doaj   +1 more source