Results 71 to 80 of about 635 (146)

Immunity to fungi in the lung. [PDF]

, 2023
The respiratory tree maintains sterilizing immunity against human fungal pathogens. Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal pathogens that form small airborne conidia.
Heung, Lena, Hohl, Tobias, Rivera, Amariliz, Wang, Keyi, Wiesner, Darin   +4 more
core   +1 more source

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

mBio, 2018
Macrophages rely on phagosomal acidity to destroy engulfed microorganisms. To survive this hostile response, opportunistic fungi such as Candida albicans developed strategies to evade the acidic environment. C. albicans is polymorphic and able to convert
Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein   +4 more
doaj   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Nature of b-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation [PDF]

, 2022
Funding Information: This work was supported by a programme grant from the UK Medical Research Council (MR/M026663/1; MR/M026663/2) and by the Medical Research Council Centre for Medical Mycology (MR/N006364/1; MR/N006364/2).
Avelar, Gabriela Mol, Bain, Judith M., Bebes, Attila, Brown, Alistair J.P., Brown, Gordon D., Childers, Delma S., da Silva, Roberta Peres, de Assis, Leandro José, Erwig, Lars P., Gow, Neil A.R., Hacker, Christian, Lagree, Katherine, Larcombe, Daniel E., Leaves, Ian, Liddle, Corin, Ma, Qinxi, Mackenzie, Kevin, Mitchell, Aaron P., Netea, Mihai G., Pradhan, Arnab, Stead, David, Yuecel, Raif   +21 more
core   +2 more sources

Pathophysiological microenvironments in oral candidiasis

APMIS, Volume 132, Issue 12, Page 956-973, December 2024.
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC.
Mette Rose Jørgensen
wiley   +1 more source

Cortactin: A major cellular target of viral, protozoal, and fungal pathogens

Molecular Microbiology, Volume 122, Issue 2, Page 165-183, August 2024.
Recent advances in research on various viral, protozoal, and fungal pathogens have deepened our understanding of microbial virulence strategies and human disease development. Cortactin, a key host protein involved in actin cytoskeletal dynamics, has emerged as crucial player in host–microbe interactions, with pathogens manipulating its expression and ...
Irshad Sharafutdinov, Barbara Friedrich, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target

Journal of Fungi, 2019
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections.
Sandeep Vellanki, Eun Young Huh, Stephen P. Saville, Soo Chan Lee   +3 more
doaj   +1 more source

Exploring the role of candidalysin in the pathogenicity of Candida albicans by gene set enrichment analysis and evolutionary dynamics

American Journal of Translational Research
To explore the pathogenic mechanisms of Candida albicans (C. albicans), focusing on its impact on human health, particularly through invasive infections in the gastrointestinal and respiratory tracts.In this study, we evaluated the demographic and clinical profiles of 7 pneumonia patients.
Xingchen Zhou, Xiaolin Chen, Qianglong Pan, Shengqi Wang, Jing Li, Ying Yang   +5 more
openalex   +4 more sources

Cross‐Sectional and Prospective Association of Serum 25‐Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes

Molecular Nutrition &Food Research, Volume 68, Issue 11, June 2024.
There is limited research conducted on the relationship between vitamin D and gut mycobiota. This study reveals that individuals with sufficient serum vitamin D exhibit a decreased abundance of fecal Saccharomyces. The results obtain from the vitamin D genetic risk score analysessupport this relationship.
Yuhui Liang, Zengliang Jiang, Yuanqing Fu, Sha Lu, Zelei Miao, Menglei Shuai, Xinxiu Liang, Wanglong Gou, Ke Zhang, Rui‐Qi Shi, Chang Gao, Mei‐Qi Shi, Xu‐Hong Wang, Wen‐Sheng Hu, Ju‐Sheng Zheng   +14 more
wiley   +1 more source

Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health

Physiological Reports, Volume 12, Issue 12, June 2024.
Abstract Although the liver is the largest metabolic organ in the body, it is not alone in functionality and is assisted by “an organ inside an organ,” the gut microbiota. This review attempts to shed light on the partnership between the liver and the gut microbiota in the metabolism of macronutrients (i.e., proteins, carbohydrates, and lipids).
Mrunmayee R. Kandalgaonkar, Virender Kumar, Matam Vijay‐Kumar   +2 more
wiley   +1 more source