Results 121 to 130 of about 23,909 (233)

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

Mapping 60 Years of Discovery: An AI‐Driven Bibliometric and Altmetric Analysis of the Journal of Periodontal Research

Journal of Periodontal Research, EarlyView.
AI, particularly the large language model GPT‐5‐mini, demonstrated reliable performance in labeling research topics and levels of evidence. Over the past 60 years, JPR has made a substantial contribution to the periodontal literature, generating meaningful public and societal impact, and it is expected to experience exponential growth in the coming ...
Parham Hazrati, Tara Zibandehkhooy, Hamoun Sabri, Mario Romandini, Shayan Barootchi   +4 more
wiley   +1 more source

Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Cannabis sativa L.). These three compounds are synthesised from a single precursor, cannabigerolic acid (CBGA), through regioselective reactions ...
Cloé Villard, Idil Baser, Arjen C. van de Peppel, Katarina Cankar, M. Eric Schranz, Robin van Velzen   +5 more
wiley   +1 more source

Effects of cannabidiol plus naltrexone on motivation and ethanol consumption [PDF]

, 2018
Adrián Viudez‐Martínez, María S. García‐Gutiérrez, Ana Isabel Fraguas‐Sánchez, Ana Isabel Torres‐Suárez, Jorge Manzanares   +4 more
openalex   +1 more source

Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9‐tetrahydrocannabinol in older patients with poor appetite

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 504-514, February 2026.
Aim Cannabis‐based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of cannabinoids have been performed in healthy adults, this study aimed to investigate the population pharmacokinetics of Δ9 ...
Ida Klitzing Storgaard, Rikke Lundsgaard Nielsen, Morten Baltzer Houlind, Olivia Bornæs, Louise Westberg Strejby Christensen, Aino Leegaard Andersen, Helle Gybel Juul‐Larsen, Lillian Mørch Jørgensen, Torben Breindahl, Baker Nawfal Jawad, Izzet Altintas, Ove Andersen, Trine Meldgaard Lund   +12 more
wiley   +1 more source

Full‐spectrum cannabidiol reduces UVB damage through the inhibition of TGF‐β1 and the NLRP3 inflammasome [PDF]

Ismael Manuel Urrutia‐Ortega, Israel Valencia, Octavio Ispanixtlahuatl-Meráz, J.C. Benítez-Flores, Adriana Montserrat Espinosa‐González, Edgar Antonio Estrella-Parra, César M. Flores-Ortíz, Yolanda I. Chirino, José Guillermo Ávila-Acevedo   +8 more
openalex   +1 more source

Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors

, 2022
Eliud Morales Dávila, Felipe Patricio, Mariana Rebolledo-Bustillo, David Garcia-Gomez, Juan Carlos García Hernández, Brenda L. Sánchez-Gaytán, Ilhuicamina Daniel Limón, Jose Manuel Perez‐Aguilar   +7 more
openalex   +1 more source

Involvement of Adenosine A2A Receptors in Anxiety‐Like Behaviors in Tetrahydrocannabinol‐Treated Mice

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study evaluated anxiety‐like behavior in mice across treatment and control groups using open field and elevated plus maze tests, followed by hippocampal receptor gene expression analysis. The combined behavioral and molecular data identify potential receptor‐level mechanisms underlying the observed treatment‐associated behavioral changes. ABSTRACT
Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü, Nermin Seda Ilgaz, Mehmet Bertan Yılmaz, Deniz Seçilmiş, Mehmet Ata Seçilmiş   +6 more
wiley   +1 more source

Diversidad y bioactividad de análogos semisintéticos de cannabidiol

, 2023
Florencia Musso
openalex   +2 more sources

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source