Results 41 to 50 of about 23,909 (233)

Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer

Frontiers in Pharmacology, 2019
Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and
Andrea Tomko, Lauren O’Leary, Hilary Trask, John C. Achenbach, Steven R. Hall, Steven R. Hall, Kerry B. Goralski, Kerry B. Goralski, Lee D. Ellis, Denis J. Dupré   +9 more
doaj   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo, Donna A. Volpe, Anik Chaturbedi, Aanchal Shah, Ashok Krishna, Paula L Hyland, Giri Vegesna, Cheng‐Hui Hsiao, Ryan De Palma, Melanie Fein, Rodney Rouse, Jeffry Florian   +11 more
wiley   +1 more source

Differences in Inhibitory Control and Resting Brain Metabolism between Older Chronic Users of Tetrahydrocannabinol (THC) or Cannabidiol (CBD)—A Pilot Study

Brain Sciences, 2022
Δ9-Tetrahydrocannabinol is the main psychoactive component of cannabis and cannabidiol is purportedly responsible for many of the medicinal benefits. The effects of Δ9-tetrahydrocannabinol and cannabidiol in younger populations have been well studied ...
Thorsten Rudroff, Craig D. Workman, Phillip E. Gander, Justin R. Deters, Laura L. Boles Ponto   +4 more
doaj   +1 more source

Cannabidiol Interacts Antagonistically with Cisplatin and Additively with Mitoxantrone in Various Melanoma Cell Lines—An Isobolographic Analysis [PDF]

, 2022
Paweł Marzęda, Paula Wróblewska-Łuczka, Małgorzata Drozd, Magdalena Florek-Łuszczki, Katarzyna Załuska-Ogryzek, Jarogniew J. Łuszczki   +5 more
openalex   +1 more source

Resolution of generalized tonic seizures following focal ablative or resective surgery

Epileptic Disorders, EarlyView.
Abstract Objective Focal brain lesions may underlie generalized tonic seizures, as seen in Lennox–Gastaut syndrome, by engaging bilateral neural networks. However, this seizure type is often not considered surgically remediable. Here, we describe the resolution of apparent electroclinically classic generalized tonic seizures in children originating ...
Sem L. Kampman, Itay Tokatly Latzer, Aaron E. L. Warren, Jurriaan M. Peters   +3 more
wiley   +1 more source

DETERMINACIÓN DE LA CAPACIDAD ANTIOXIDANTE DE UNA CREMA ELABORADA CON EXTRACTO ISOLADO DE CANNABIDIOL DE Cannabis sativa L. (CÁÑAMO)

infoANALITÍCA
En la presente investigación se determinó la capacidad antioxidante de una crema cosmética facial, elaborada a partir del extracto aislado (isolado) de cannabidiol. Para establecer la capacidad antioxidante.
Nataly Arciniegas S., Carlos Vélez, Daniela Coloma, Edison Osorio   +3 more
doaj   +1 more source

Cannabidiol revisited [PDF]

IUCrData, 2017
The crystal structure of cannabidiol, C21H30O2, {systematic name: 2-[(1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-enyl]-5-pentylbenzene-1,3-diol}, was determined earlier by Joneset al.[(1977).Acta Cryst.B33, 3211–3214] and Ottersen & Rosenqvist [(1977).Acta Chem. Scand.B31, 749–755].
Tobias Mayr, Tobias Grassl, Nikolaus Korber, Volker Christoffel, Michael Bodensteiner   +4 more
openaire   +3 more sources

Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study

Epilepsia, EarlyView.
Abstract Objective CDKL5 deficiency disorder (CDD) is a rare X‐linked developmental and epileptic encephalopathy caused by loss‐of‐function variants in the CDKL5 gene. Preclinical experiments using enzyme replacement or gene therapies show promise and could be transformative therapies.
Xavier Liogier d'Ardhuy, CANDID Partners, Tricia Cimms, Kristina Lindsten, Marco Rizzo, Alison Skrinar, Peter St. Wecker, Ana Mingorance, Orrin Devinsky   +8 more
wiley   +1 more source

Cannabidiol impairs sperm quality and function in adult mice

Middle East Fertility Society Journal
Background Considering the growing therapeutic use of cannabidiol as well as the presence of cannabinoid receptors in sperm and its possible genotoxic activity, the effect of cannabidiol on sperm quality and function was examined.
Azam Govahi, Sahar Eghbali, Marziyeh Ajdary, Fatemehsadat Amjadi, Mahsa Nazari, Farzaneh Mohammadzadeh Kazorgah, Mehdi Mehdizadeh   +6 more
doaj   +1 more source

Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

Heliyon, 2021
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described.
Lisa A. Stott, Cheryl A. Brighton, Jason Brown, Richard Mould, Kirstie A. Bennett, Robert Newman, Heather Currinn, Flavia Autore, Alicia P. Higueruelo, Benjamin G. Tehan, Cliona MacSweeney, Michael A. O'Brien, Steve P. Watson   +12 more
doaj   +1 more source